85 studies on Sermorelin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
These findings strongly suggest that GHRH antagonists could be a potent new therapeutic strategy for advanced prostate cancer by simultaneously inhibiting tumor growth and its ability to spread. The observed reduction…
This review underscores that peptide-based therapies represent a crucial and evolving frontier in the management of advanced prostate cancer, offering targeted mechanisms to combat disease progression. The insights ga…
This research highlights a novel strategy to enhance the efficacy of existing chemotherapy regimens for colon cancer by targeting the GHRH pathway. The observed additive growth inhibition and induction of S-phase arre…
This research highlights a promising new therapeutic strategy for triple-negative breast cancer, a disease with limited treatment options and a high unmet medical need. The synergistic effects observed with GHRH antag…
This research provides compelling evidence that activating GHRH signaling can effectively counteract the neurodegenerative processes triggered by intermittent hypoxia. This suggests that GHRH agonists could represent …
This study highlights the therapeutic potential of GHRH antagonists as a novel and targeted strategy for treating malignant melanoma, a cancer with high unmet medical needs. By demonstrating that these compounds resto…
These findings are highly significant as they identify pGHRH-R as a viable therapeutic target in papillary thyroid cancer and demonstrate the potent anti-proliferative and anti-invasive effects of GHRH antagonists. Th…
This research highlights a novel therapeutic strategy for heart failure post-MI by targeting the GHRH receptor, which is often overexpressed in damaged hearts and contributes to pathological remodeling. The significan…
This study provides compelling evidence that GHRH agonists can significantly reduce heart attack scar tissue and improve heart function in a large animal model, offering a novel therapeutic strategy for ischemic cardi…
This research highlights GHRH analogs as a promising new class of therapeutic agents for enhancing wound healing. By directly stimulating the proliferation and survival of human dermal fibroblasts, these compounds cou…
This research highlights the significant potential of GHRH receptor antagonists as a novel and targeted therapeutic strategy for gastric cancer. By demonstrating their ability to inhibit tumor growth and induce apopto…
This study's findings are significant as they highlight the potential of Growth Hormone Secretagogues (GHS) to effectively elevate IGF-1 levels in hypogonadal men, a population often struggling with associated metabol…
This study provides compelling and robust evidence that GHRH agonists represent a promising novel therapeutic strategy for preventing the onset and progression of early diabetic retinopathy. By simultaneously targetin…
These findings highlight GHRH receptor antagonists as a promising therapeutic strategy for prostate cancer by targeting multiple pathways involved in tumor growth and angiogenesis. The ability to inhibit both cell pro…
This study provides compelling evidence that GHRH analogs possess significant anti-inflammatory, antioxidant, and beneficial behavioral properties, extending their therapeutic potential beyond endocrine regulation. Th…
These findings are significant because they identify the GHRH receptor as a crucial modulator of acute ocular inflammation, expanding its known physiological roles beyond growth hormone regulation. The observed anti-i…
This comprehensive review significantly expands our understanding of GHRH's multifaceted roles beyond its traditional endocrine function, particularly its involvement in cancer progression and lung inflammation. The c…
This research highlights a significant new therapeutic potential for GHRH antagonists, particularly MIA-602, in conditions involving blood-brain barrier dysfunction. Given their ability to protect brain microvascular …
This study provides compelling preclinical evidence that GHRH agonists could represent a novel and effective therapeutic strategy for CKD-induced HFpEF, a condition with high morbidity and mortality. The observed impr…
This research is highly significant as it introduces sermorelin as a novel and potentially effective therapeutic candidate for recurrent glioma, a condition with extremely limited treatment options and a dire prognosi…
This research highlights a novel therapeutic strategy for protecting retinal ganglion cells after optic nerve injury by leveraging the body's own immune system. The ability of a GHRH agonist to shift macrophage polari…
This research highlights MIA-602 as a novel therapeutic approach for PTSD by targeting the GHRH receptor, offering a new mechanism of action beyond existing treatments. The significant improvements observed across mul…
This advanced analytical method represents a significant leap forward for the characterization of GHRH analogs. The ability to precisely separate and quantify enantiomers with high sensitivity is critical for ensuring…
This study highlights MR-409 as a promising therapeutic candidate for preventing beta-cell destruction, a critical step in managing Type 1 Diabetes and potentially other forms of diabetes where beta-cell loss is a fac…
This research provides crucial analytical standards and degradation profiles that can significantly enhance anti-doping detection capabilities. By understanding how these peptides break down, forensic laboratories can…
This study highlights MIA-602 as a promising novel therapeutic strategy for mitigating SARS-CoV-2-induced cardiopulmonary injury, moving beyond purely antiviral approaches. By targeting the GHRH receptor, MIA-602 offe…
This study highlights that MIA-602 represents a novel, targeted therapeutic approach for Acute Myeloid Leukemia, by effectively antagonizing the GHRH pathway. Given the significant unmet need for more effective and le…
This research highlights a promising new strategy to overcome radioresistance in NSCLC, a major challenge in oncology. By targeting the GHRH pathway, MIA-602 appears to sensitize cancer cells to radiation, potentially…
This research provides crucial insights, suggesting that the anti-cancer effects of GHRH antagonists may be mediated, at least in part, through the induction of autophagy. Autophagy can lead to programmed cell death o…
This study represents a significant advancement in the fight against doping in sports, specifically targeting growth hormone releasing hormone synthetic analogs. By identifying and characterizing previously unknown me…
This highly sensitive and robust nano LC-Q/Orbitrap MS method represents a significant advancement in the detection of GHRH and its analogs, which are frequently abused performance-enhancing drugs. The enhanced sensit…
The ability of Sermorelin to stimulate the body's natural GH production offers a significant advantage over direct GH replacement, potentially reducing side effects and maintaining physiological feedback loops. This a…
This study is significant because it confirms the sustained efficacy and long-term safety of TH9507 (Tesamorelin) as a targeted treatment for HIV-associated lipodystrophy, a challenging side effect of ART. Reducing vi…