621 studies on Semaglutide curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
If successful, this study could establish semaglutide as a safe and effective treatment option for glucose control in patients with Type 2 Diabetes and End Stage Renal Disease on dialysis. This is a particularly chall…
The findings from this trial are profoundly significant, as oral semaglutide offers a highly effective, non-injectable treatment option for Type 2 Diabetes Mellitus. This oral formulation has the potential to revoluti…
Understanding the safety and tolerability of BI 1820237 is a critical first step in its development as a potential new treatment for overweight and obesity. If BI 1820237 demonstrates a favorable safety profile and pr…
This trial addresses a significant gap in post-TAVR care, as current medical therapies do not adequately reduce long-term cardiovascular risks. If successful, this study could establish semaglutide as a crucial adjunc…
This research is crucial because it aims to provide a deeper understanding of how Semaglutide improves outcomes in Type 2 Diabetes beyond just weight loss and blood sugar control. By specifically targeting intramyocel…
This study addresses a critical need for practical, accessible dietary recommendations to complement GLP-1 RA therapy, potentially enhancing patient outcomes beyond just weight loss. If successful, it could provide a …
This study is pivotal as it explores a novel, multimodal approach to pre-surgical optimization for a high-risk patient population. If successful, the findings could revolutionize the standard of care for obese patient…
Had it been completed, this registry would have provided an invaluable real-world dataset for understanding the long-term trajectory of obesity and metabolic diseases, offering insights into how these conditions evolv…
This systematic review highlights the significant therapeutic potential of incretin-based therapies for individuals struggling with binge eating disorder, offering a promising new avenue for treatment. Given that curr…
This study provides crucial evidence that early intervention with tirzepatide and semaglutide can significantly mitigate the progression of atherosclerosis, a leading cause of morbidity and mortality worldwide. The ob…
This study provides compelling evidence that Semaglutide offers significant renoprotective benefits in a non-diabetic model of kidney injury, extending its potential therapeutic utility beyond metabolic diseases. The …
This research provides crucial insights, strongly suggesting that the weight loss achieved with Semaglutide is the primary driver behind its beneficial effects on liver health in patients with Type 2 Diabetes Mellitus…
This real-world study is crucial for understanding the practical effectiveness of oral semaglutide in a specific demographic, providing valuable data beyond controlled clinical trials. The findings, once published, co…
Understanding the genetic underpinnings of oral semaglutide response is crucial for advancing personalized medicine in prediabetes and obesity. This research could pave the way for personalized treatment strategies, o…
This ambitious trial holds the potential to transform the management of cardiovascular risk in Type 1 Diabetes, particularly for those at high risk. If successful, the findings could establish a new standard of care a…
This trial holds significant promise as it explores a novel therapeutic strategy for a complex and underserved patient population. If semaglutide proves effective in reducing alcohol intake and smoking, it could offer…
The successful demonstration of bioequivalence between these two Semaglutide concentrations is critically important for manufacturing flexibility and potentially expanding treatment options. This allows Novo Nordisk t…
This study is profoundly significant because GLP-1RAs could offer a dual benefit for Type 2 Diabetes patients, simultaneously managing blood glucose and addressing nicotine dependence, a major and often overlooked com…
Obesity-related male infertility is a growing concern, and current treatments often lack sustained efficacy or adherence. This trial holds the potential to identify a novel and effective pharmacological intervention f…
This case report provides compelling evidence that oral semaglutide could be a highly effective and well-tolerated treatment option for patients with HNF4A-MODY, potentially offering a valuable alternative to traditio…
This research highlights a potentially novel benefit of GLP-1 receptor agonists beyond their established metabolic effects, suggesting they may play a protective role in surgical recovery. The significant reduction in…
This comprehensive update underscores the critical and evolving role of non-invasive tests in the diagnosis and management of Steatotic Liver Disease, marking a significant shift away from reliance on invasive liver b…
This real-world comparative study provides crucial insights into the relative effectiveness of leading weight loss medications outside of controlled clinical trials. The findings strongly support Tirzepatide's superio…
This research is critically important because it addresses a significant unmet need for overweight type 2 diabetic patients with IBD, a population facing compounded health challenges. Current IBD therapies are often l…
Understanding ethnic differences in drug response is critical for optimizing dosing and ensuring drug safety globally. Data from studies like this help inform appropriate prescribing practices for diverse populations,…
This study is crucial because reducing epicardial fat volume could be a novel therapeutic target for improving outcomes in patients who have suffered a STEMI. Both Dapagliflozin and Semaglutide have demonstrated cardi…
If successful, this study could highlight a novel therapeutic benefit of semaglutide beyond its established roles in glycemic control and weight management. Identifying an effective pharmacological intervention for di…
As an active study (NCT07417618) not yet recruiting, specific results are not available; however, based on existing clinical trial data and the known mechanisms of these drugs, the study is expected to reveal signific…
The findings from this review highlight a novel therapeutic pathway for Alcohol Use Disorder (AUD), leveraging Semaglutide's known effects on appetite and reward systems. Given the significant unmet need for effective…
This comprehensive network meta-analysis provides robust evidence confirming the superior efficacy of GLP-1 receptor agonists in achieving clinically significant weight loss in nondiabetic adults. The findings highlig…
This comprehensive review underscores the significant potential of GLP-1 RAs as novel therapeutic agents for a range of psychiatric disorders, extending their utility beyond metabolic health. Their established safety …
This retraction is a critical reminder of the importance of scientific integrity and rigorous peer review in maintaining the reliability of medical literature. It underscores that any conclusions or recommendations ba…
This scoping review is crucial for informing clinical guidelines and best practices for orthopedic surgeons, anesthesiologists, and perioperative care teams. Understanding the current evidence base regarding GLP-1 RA …
This review provides a strong theoretical and preliminary clinical basis for exploring GLP-1 RAs as novel adjuncts to cancer immunotherapy. The observed immunomodulatory effects and potential for enhanced efficacy, co…
This study highlights the critical importance of considering sex as a biological variable in metabolic research and drug development. The enhanced FGF21 response and profound metabolic improvements observed specifical…
This FDA approval of higher-dose semaglutide marks a significant advancement in the pharmacological treatment of obesity, offering a highly effective option for chronic weight management. The substantial and sustained…