87 studies on Orexin a curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research highlights **orexin-A** as a potential biomarker for **Major Depressive Disorder**, particularly for identifying specific symptom clusters beyond sleep and cognition. The finding that short-term antidepr…
Identifying distinct sleep quality profiles in youth with eating disorders could significantly impact clinical practice by enabling more **personalized and targeted interventions**. Instead of a one-size-fits-all appr…
This review significantly advances our understanding of **PTSD** beyond traditional psychological models, underscoring the critical role of the gut-brain axis. **For clinicians and biohackers, it opens new avenues for…
Understanding the distinct roles of `SST-14` and `SST-28`, along with their specific `SSTR` interactions, is critical for developing targeted therapies for age-related **CNS and GI tract diseases**. This foundational …
This review underscores the critical importance of metabolic health for preventing and mitigating **neurodegenerative diseases** like **Alzheimer's**. For peptide users and biohackers, it highlights that optimizing me…
Without specific findings, the immediate practical implications remain prospective. However, if successful, this research could **inform future dietary recommendations for postmenopausal women**, potentially offering …
If successful, this study could establish **Lemborexant** as a valuable adjunct therapy for managing residual insomnia in individuals with **Opioid Use Disorder** on buprenorphine. **Improving sleep quality in this po…
This research identifies a novel and specific neural circuit, the **LH-vlPAG orexinergic pathway**, through which **Neuropeptide S** can alleviate **neuropathic pain**. **Targeting the NPS system or its downstream ore…
This first nationwide, real-world characterization of central disorders of hypersomnolence in Italy provides critical insights into the prevalence and clinical presentation of these conditions. **The registry highligh…
This study suggests that **orexin-A** could serve as a specific biomarker for certain affective dimensions of **Major Depressive Disorder**, particularly 'apparent sadness,' rather than a broad indicator of overall de…
Identifying novel genes like **NPVF** that are highly expressed in **hypocretin** neurons offers critical new directions for investigating the pathophysiology of **Narcolepsy Type 1**. **This research could lead to th…
Shenling Jiangzhi Formula (SJF) reduced atherosclerotic plaque formation and vascular inflammation in ApoE-/- mice by targeting the `NF-κB`/`NLRP3` pathway.
**This study reinforces the orexin system, particularly `OX1R` and `OX2R` in the hippocampus, as a promising target for novel antidepressant therapies, especially for stress-induced depression.** The finding that anta…
This ambitious cohort study is crucial for advancing our understanding of chronic hypersomnolence by providing a rich, integrated dataset. The collected data will be instrumental in identifying novel biomarkers for di…
The findings from this study, once published, could significantly advance our understanding of GLP-1 agonists beyond weight loss, specifically in treating binge eating disorder. If Liraglutide proves effective, it cou…
Understanding the direct biological links between chronic insomnia and dementia biomarkers could revolutionize early detection and intervention strategies. If specific CSF markers are reliably associated with chronic …
This Phase 2 long-term extension study is crucial for understanding the sustained impact of ORX750 on chronic sleep disorders, moving beyond short-term efficacy data. Long-term safety and sustained efficacy are paramo…
This research could provide a novel, non-invasive treatment option for the challenging comorbidity of depression in narcolepsy patients. If successful, iTBS could offer a well-tolerated alternative or adjunct to exist…
The development of effective, comprehensive intervention techniques for adolescent depression is paramount, given the high prevalence and profound impact of this condition on young lives and public health systems. Thi…
These promising Phase 2 results suggest that ALKS 2680 could offer a novel, effective, and well-tolerated treatment option for Narcolepsy Type 1, directly addressing both excessive daytime sleepiness and cataplexy. Th…
This study is crucial because it could establish continuous glucose monitoring (CGM) as a superior standard of care for managing hyperglycemia in hospitalized patients, potentially reducing inflammation and improving …
If successful, this study could validate PS150 as a novel, non-pharmacological intervention for insomnia, offering a natural alternative to traditional sleep aids. The findings could highlight the critical role of the…
This research significantly advances our understanding of the brain's hedonic circuitry, pinpointing the olfactory tubercle as a critical "hedonic hotspot" for taste pleasure. The identification of specific neurochemi…
While specific findings from this preliminary study are not detailed, the research direction itself holds significant potential. If Orexin A is confirmed to play a crucial role in **alpaca fertility** through its effe…
The review identified significant neurobiological overlaps between Anorexia Nervosa (AN) and addiction-like features, particularly within the dopaminergic, endocannabinoid, and orexinergic systems. Dysregulation in th…
This study provides crucial objective evidence linking persistent sleep disturbances after mTBI to specific hormonal imbalances, particularly dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and melatoni…
This research highlights a novel neuroprotective role for Orexin-A beyond its established functions in sleep and appetite, specifically in modulating neuroinflammatory responses. The finding that Orexin-A can inhibit …
This research highlights a fundamental, stable neural mechanism involving orexin-A neurons that underlies the acute stress response, operating independently of the more variable hormonal profiles across different life…
Understanding the genetic and clinical heterogeneity of narcolepsy across diverse ethnic groups is crucial for improving diagnosis and personalized treatment strategies. This research could lead to the identification …
Shift-Work Sleep Disorder and associated stress are prevalent and serious issues, particularly among healthcare workers, impacting both personal well-being and potentially patient safety. Non-pharmacological intervent…
This pilot study provides compelling preliminary evidence that liraglutide could offer a novel therapeutic approach for sleep apnea in non-diabetic individuals, potentially independent of its weight-loss effects. The …
The PubChem profile unequivocally identifies Orexin A through its unique Compound ID (CID): 56842143, a standard identifier in chemical databases. It precisely outlines the peptide's complex molecular formula as C152H…
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