83 studies on SS-31 curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
Independent certificate-of-analysis evidence from third-party labs — the data behind the studies. Updated as new COAs are verified.
| Manufacturer | Batches | Avg purity | |
|---|---|---|---|
| Allen Biotechnology Co Abc | 7 | 99.35% | View COA → |
| (unknown) | 6 | 99.79% | View COA → |
| GYC | 6 | 99.44% | View COA → |
| Qingdao Sigma Chemical | 4 | 99.77% | View COA → |
| Top Peptide | 3 | 99.9% | View COA → |
| FSD | 3 | 99.79% | View COA → |
| Barn | 2 | 99.83% | View COA → |
| ASC | 2 | 99.8% | View COA → |
Recent certificates: #11900 (99.727%) · #13513 (99.699%) · #12219 (99.843%) · #14591 (99.811%) · #10175 (99.743%) · #11908 (99.74%)
Manufacturers with published third-party certificates of analysis for SS-31. Open a vendor to see every batch we've verified.
This study highlights the neuroprotective and regenerative potential of Elamipretide (SS-31) in the context of spinal cord injury. By directly targeting mitochondrial dysfunction and promoting neural remodeling, Elami…
This mechanistic understanding is crucial because it identifies mitochondrial dysfunction as a central, actionable target for preventing β-cell loss in T2DM. By elucidating the precise links between mitochondrial heal…
This research is significant because it identifies Quercetin, a natural flavonoid, as a potential therapeutic agent for renal ischemia-reperfusion injury, a condition with limited current treatment options. The findin…
This review is crucial because it highlights the urgent need for effective treatments for dry AMD, a condition affecting millions globally with no current cure. The identification of innovative technologies like gene …
This groundbreaking study introduces a highly effective and targeted strategy for delivering thermogenic agents, presenting a novel and potentially safer pathway for obesity treatment. By specifically boosting mitocho…
This comprehensive review underscores the critical role of mitochondria as a promising therapeutic target for preventing and treating acute kidney injury (AKI) caused by ischemia-reperfusion injury (IRI). By elucidati…
This review significantly advances our understanding of Diabetic Kidney Disease (DKD) by firmly establishing mitochondrial dynamics as a crucial pathogenic mechanism. Identifying specific pathways within mitochondrial…
SS-31 represents a highly promising therapeutic strategy for a wide range of conditions characterized by mitochondrial dysfunction, offering a direct and targeted approach to cellular protection. Its unique ability to…
This review provides novel insights into the critical role of mitochondrial calcium dysregulation in heart failure, underscoring its potential as a therapeutic target. The discussion of mCa2+ uniporter (MCU) inhibitor…
This research highlights SS-31 as a promising therapeutic agent for tendinopathy by targeting mitochondrial health, a critical factor in tissue repair and regeneration. The ability of SS-31 to protect mitochondria and…
This research highlights the significant potential of Elamipretide as a therapeutic agent for promoting healthy aging and potentially extending healthspan. By targeting mitochondrial function, Elamipretide appears to …
Sepsis-associated encephalopathy (SAE) represents a critical unmet medical need, with current treatments offering limited efficacy against its severe cognitive sequelae. This research provides compelling evidence that…
This research underscores aging as a critical and independent risk factor that significantly amplifies the heart's vulnerability to dietary sugar. The findings suggest that older individuals may require more stringent…
This study provides compelling evidence that SS-31 peptide can mitigate severe cardiac mitochondrial dysfunction in a genetic model of Barth syndrome, suggesting its potential as a novel therapeutic strategy. By impro…
This study highlights the inherent resilience of the gut microbiota in a non-Western population, suggesting that while antibiotics cause significant disruption, the microbiome can largely recover its diversity and com…
This research significantly advances our understanding of spinal cord injury pathology by identifying a critical role for cPLA2-mediated lysosomal membrane permeabilization in driving pyroptosis. The finding that Elam…
This research highlights the potential of synovial fluid mtDNA as a novel, non-invasive biomarker for assessing cartilage damage severity after joint injury. Such a biomarker could significantly improve early diagnosi…
This review highlights the critical role of mitochondrial health in NAFLD pathogenesis and underscores the immense potential of mitochondrial-targeted therapies. By summarizing the efficacy of various compounds and me…
This research highlights SS-31 as a promising therapeutic agent for combating age-related cerebrovascular dysfunction by directly targeting mitochondrial health. The observed proteomic improvements suggest that SS-31 …
This research is significant because it identifies a specific mechanism by which elamipretide (SS-31) can counteract age-related mitochondrial decline. By improving ADP sensitivity and enhancing ANT function, SS-31 co…
Understanding these intricate molecular mechanisms is profoundly crucial for the rational design and optimization of more effective mitochondria-targeted therapeutics. By elucidating precisely how specific peptide seq…
This research provides compelling evidence for Elamipretide's therapeutic potential in treating Idiopathic Pulmonary Fibrosis by targeting a crucial inflammatory and fibrotic pathway. The ability of Elamipretide to mo…
The successful application of SS-31 as a mitochondrial-targeted antioxidant represents a significant advancement in therapeutic strategies for diseases driven by mitochondrial pathology. By directly addressing the roo…
This review underscores the transformative potential of biomaterial-based drug delivery for inflammasome inhibitors, offering a pathway to overcome current therapeutic limitations. By enabling targeted and sustained r…
This research highlights mitochondrial ROS as a crucial mechanistic driver of calcium alternans in atrial myocytes, offering a novel perspective on the pathogenesis of atrial fibrillation (AF). The findings suggest th…
This research is significant because it identifies a novel therapeutic strategy for POCD, a condition with limited effective treatments, especially in the elderly. By targeting mtDNA-cGAS-STING signaling and activatin…
This research highlights SS-31 as a promising therapeutic candidate for hepatic fibrosis by simultaneously targeting mitochondrial dysfunction and NLRP3 inflammasome-mediated inflammation. The ability of SS-31 to dire…
This discovery represents a pivotal breakthrough in understanding the mechanism of action of SS-31, a drug with significant therapeutic potential across a range of mitochondrial dysfunction-related diseases. Identifyi…
These findings underscore SS-31's significant potential as a novel therapeutic agent for managing and treating inflammatory liver conditions. By elucidating its mechanism through ATG5-dependent autophagy, this researc…
This research highlights Elamipretide's significant potential as an additive to cryopreservation solutions, offering a novel strategy to mitigate cellular damage during ovarian tissue vitrification. By protecting mito…
This study highlights elamipretide's significant potential as a therapeutic agent for combating cognitive impairments associated with chronic sleep deprivation. Its ability to directly target and restore mitochondrial…
This study provides compelling evidence that MitoPeptide-X can effectively reverse skeletal muscle mitochondrial dysfunction and improve muscle performance in a preclinical model of metabolic disease. This identifies …
This research highlights SS-31 as a promising therapeutic candidate for Barth syndrome, directly targeting the mitochondrial dysfunction central to the disease's pathology. By ameliorating mitochondrial morphology and…
This research highlights SS-31's potential as a therapeutic agent for mitigating cellular damage caused by cigarette smoke, offering a novel approach to combat oral diseases. By targeting mitochondrial dysfunction and…
This extensive review highlights the critical and multifaceted role of mitochondrial dysfunction in driving the aging process and underscores the significant therapeutic potential of targeting these organelles. The co…
This review underscores the pivotal role of mitochondria in determining the trajectory of recovery and long-term neurological health after TBI. By identifying mitochondrial dysfunction as a key pathological mechanism,…
This discovery of SS-31-X represents a significant advancement in the development of mitochondrial-targeting therapeutics. The observed enhanced efficacy in protecting mitochondrial function and reducing oxidative str…
This research provides compelling evidence that SS-31 (elamipretide) is a highly promising therapeutic agent for treating diabetic cardiomyopathy. The identification of its mechanism of action, specifically through th…
The combination of H/R and SPIONs (50 µg/mL) significantly induced ferroptosis in cardiomyocytes, resulting in a 45% reduction in cell viability and a 2.8-fold increase in lipid peroxidation (MDA levels) compared to u…
This research highlights the critical role of mitochondrial health in mitigating the long-term debilitating effects of sepsis on muscle function. The findings suggest that targeting mitochondrial dysfunction could rep…
This study's findings are highly significant as they demonstrate a novel and effective therapeutic strategy that simultaneously targets multiple critical pathological mechanisms of Alzheimer's disease: mitochondrial d…
This study presents a highly promising regenerative strategy for intervertebral disc degeneration by directly targeting mitochondrial dysfunction, a fundamental cause of disc breakdown. The ability of the multifunctio…
This study provides compelling evidence that SS-31@Fer-1 can effectively prevent ferroptosis in heart cells following hypoxia/reoxygenation injury, offering a critical new strategy to reduce damage after events like h…