Hepatocyte Mitochondrial DNA Drives Macrophage Inflammation in Trichloroethylene Liver Injury

Exposure to Trichloroethylene (TCE), a prevalent environmental pollutant, is a known cause of severe liver injury and hepatotoxicity. While direct damage to liver cells (hepatocytes) is understood, the precise mechanisms by which TCE triggers a broader immune response, particularly involving macrophages, have remained elusive. This study specifically sought to uncover the role of hepatocyte mitochondrial DNA (mtDNA) in mediating the macrophage-driven immune response during TCE-induced liver damage.