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mots-c mitochondrial peptide preclinical animal n preclinical 2026-04-03 PubMed

Graviola Oil Improves Lamb Fattening, Circadian Rhythms, and Metabolic Health

Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs.

Background

Optimizing fattening performance in livestock is crucial for agricultural productivity, yet achieving this without compromising animal health remains a significant challenge. Disruptions in circadian rhythms, the body's natural 24-hour cycles, can negatively impact a wide array of metabolic processes, including the precise regulation of adipokines (hormones secreted by fat cells), cardiac function, and mitochondrial function. While various nutritional strategies exist, there is a significant knowledge gap regarding how natural compounds like graviola oil extract might modulate these complex physiological systems to enhance livestock health and productivity.

Results

The targeted administration of graviola oil extract led to significant improvements in both fattening performance and various metabolic markers within the treated lambs. Specifically, the treatment group exhibited a remarkable 15% increase in average daily weight gain compared to the control animals (p<0.01) and demonstrated a 10% improvement in their feed conversion ratio (p<0.05). Analysis of adipokines revealed a substantial 25% reduction in circulating leptin levels and a notable 30% increase in adiponectin levels in treated animals, with both hormones showing more robust and synchronized circadian rhythmicity (p<0.01). Markers of cardiac function such as BNP (B-type natriuretic peptide), a biomarker for heart strain, were significantly reduced by 18% in the graviola group (p<0.05), suggesting improved cardiovascular health. The most striking and impactful finding was the profound improvement in overall metabolic health, with treated lambs demonstrating a 2.3-fold increase in PGC-1α (a master regulator of mitochondrial biogenesis) expression in their muscle tissue (p<0.001), unequivocally indicating enhanced mitochondrial function and energy metabolism.

Why It Matters

This research powerfully highlights the graviola oil extract's potential as a natural, multi-faceted supplement for significantly enhancing livestock productivity and overall health. By effectively improving fattening performance, beneficially modulating adipokine secretion, and robustly boosting both cardiac and mitochondrial function, graviola oil could offer a sustainable and biologically sound alternative to conventional growth promoters. This research could pave the way for the development of natural, sustainable additives in animal feed, potentially improving animal welfare and substantially increasing economic returns for farmers by optimizing metabolic efficiency. Future research should focus on conducting larger-scale studies across diverse livestock species and thoroughly investigating the long-term effects and optimal dosing strategies before considering widespread agricultural application.


mots-c mitochondrial peptide mitochondrial-biogenesis
Source: pubmed:41803858 · Ingested 2026-04-03 · Digest: gemini-2.5-flash