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Humanin 2026-10-24 PubMed

Humanin Variants Differentially Regulate BID Fibrilization, Suppressing BAX- and BID-Dependent Membrane Permeabilization

Humanin variants differentially regulate BID fibrilization and suppress BAX- and BID-dependent membrane permeabilization.

Abstract

Humanin variants differentially regulate BID fibrilization, with specific residues dictating interactions, ultimately suppressing BAX- and tBID-mediated membrane permeabilization. This clarifies HN's cytoprotective mechanism.


Source: pubmed:42918500 · Ingested Oct 23, 2026 · Digest: gemini-2.5-flash