83 studies on SS-31 curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research fundamentally shifts our understanding of how telomere length is established and inherited, demonstrating its modifiability during the earliest stages of embryonic development. The ability to intervene w…
This research underscores the critical importance of mitochondrial health in preventing age-related cerebral microhemorrhages, offering a highly promising therapeutic strategy. The findings suggest that SS-31 could em…
This research highlights the therapeutic potential of SS-31 as a novel treatment strategy for pulmonary fibrosis by targeting mitochondrial dysfunction and oxidative stress, key drivers of the disease. Given the curre…
This research provides crucial insights into the molecular mechanisms underlying angiotensin II-induced kidney damage, highlighting Sirt6 as a key regulator of lipid metabolism in podocytes. The findings suggest that …
This research provides crucial insights into the early molecular events following traumatic muscle injury, identifying acute mitochondrial ROS as a central player in the ensuing dysfunction. Targeting these early ROS …
This study provides compelling evidence that targeting mitochondrial dysfunction with MitoRenin can effectively reverse key pathological features of kidney disease progression, including both functional impairment and…
This research highlights SS-31 as a potent therapeutic candidate for combating age-related decline in bone formation by targeting mitochondrial health and NOS2 activity. The ability of SS-31 to restore mitochondrial f…
This research identifies YTHDF1 as a novel and critical regulator of allergic airway inflammation and mitochondrial dysfunction, offering a new perspective on asthma pathogenesis. By elucidating its interaction with t…
This research provides compelling evidence that mitochondrial dysfunction is a primary driver of age-related aortic degeneration. The successful intervention with elamipretide highlights its potential as a therapeutic…
This study provides compelling evidence that Szeto-Schiller 31 can effectively alleviate acute lung injury in neonatal mice by targeting critical inflammatory pathways. The ability of SS-31 to suppress TXNIP expressio…
This research highlights the critical importance of standardized and optimized quenching protocols in environmental water analysis. Inaccurate DBP profiles due to improper sample handling could lead to misjudgments of…
This case report, supported by existing evidence, suggests that elamipretide holds significant promise as a targeted therapy for Barth Syndrome, directly addressing the core mitochondrial dysfunction. The observed imp…
This study provides compelling evidence that patient self-selection for ream-and-run arthroplasty does not negatively influence postoperative outcomes, including pain, function, and satisfaction. This finding is signi…
This research highlights SS-31's novel mechanism of action in neuroprotection, specifically by targeting microglial ferroptosis and modulating their inflammatory state. The ability to shift microglia towards a protect…
This scoping review provides a crucial roadmap for future research by consolidating the diverse landscape of peptides being explored for skeletal muscle wasting. It highlights the significant therapeutic potential of …
This research provides strong evidence that mitochondrial dysfunction is a primary driver of aortic aging, offering a novel understanding of age-related cardiovascular decline. The successful restoration of mitochondr…
This research highlights the critical role of endothelial glycocalyx integrity in maintaining cognitive function during aging and suggests that SS-31 could be a promising therapeutic agent. By protecting the glycocaly…
This review underscores the transformative potential of nanoliposomal technology for improving human health by revolutionizing nutrient and drug delivery. By enhancing bioavailability and enabling targeted action, nan…
This study highlights SS-31's potential as a therapeutic agent for improving female fertility, particularly in cases of advanced maternal age. By directly targeting mitochondrial dysfunction, a central mechanism of oo…
This research is significant because it identifies hippocampal mitochondrial dysfunction as a central mechanism underlying opioid-induced postoperative cognitive dysfunction in aged individuals. By pinpointing specifi…
This review underscores the immense therapeutic potential of mitochondria-derived peptides as a novel class of agents for treating cardiovascular diseases. By directly targeting mitochondrial dysfunction, MDPs offer a…
The findings underscore the significant therapeutic potential of mitochondrial-derived peptides as a novel class of agents for preventing and treating vascular aging and associated cardiovascular diseases. By targetin…
This review significantly advances our understanding of mitochondria-derived peptides (MDPs) as critical regulators of hepatic metabolism and potential therapeutic agents. The identification of MDPs like MOTS-c and Hu…
SS-31 represents a highly promising therapeutic strategy for a wide range of conditions characterized by mitochondrial dysfunction, offering a direct and targeted approach to cellular protection. Its unique ability to…
Friedreich Ataxia (FRDA) currently lacks effective treatments for vision loss, a symptom that significantly impacts patients' independence and quality of life. Positive results from this pilot study could validate Ela…
This research highlights the significant therapeutic potential of N-Acetylcysteine and especially Elamipretide (SS-31) as interventions for ozone-induced respiratory injury. Given that Elamipretide specifically target…
This research highlights a novel therapeutic strategy for ischemic stroke by targeting mitochondrial cardiolipin homeostasis. The findings suggest that modulating cardiolipin can effectively interrupt the damaging cas…