Patulin Toxin Triggers Kidney Cell Death via Mitochondrial and JAK2/STAT3 Pathway Dysfunction
The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure.
Background
Exposure to patulin, a common mycotoxin found in moldy fruits, poses a significant health risk, particularly to the kidneys. While patulin is known to induce renal cell injury, the precise mechanisms leading to programmed cell death in these cells have remained unclear. This study specifically investigates how patulin exposure leads to necroptosis in renal cells, focusing on the roles of mitochondrial dysfunction and the JAK2/STAT3 signaling pathway.