SS-31 Peptide Shows Strong Neuroprotective Effects After Spinal Cord Injury
Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, Exerts Neuroprotective Effects Within In Vitro and In Vivo Models of Spinal Cord Injury.
Background
Spinal cord injury (SCI) is a devastating neurological condition leading to severe and often permanent functional deficits. The initial mechanical trauma is followed by a cascade of secondary injury events, including mitochondrial dysfunction, oxidative stress, and inflammation, which exacerbate neuronal death and hinder recovery. Current therapeutic options for SCI are limited and largely ineffective at preventing this secondary damage. This study addresses the critical need for novel neuroprotective strategies that target mitochondrial health to mitigate secondary injury and improve functional outcomes following SCI.