NNT Enzyme Reduces Brain Cell Inflammation After Spinal Cord Injury

Spinal cord injury (SCI) often leads to severe and permanent neurological deficits, not only from the initial trauma but also from secondary damage. A major contributor to this secondary damage is neuroinflammation, primarily driven by the activation of microglia (the resident immune cells of the central nervous system). This persistent inflammatory response exacerbates neuronal death and significantly hinders functional recovery. Understanding novel pathways to modulate microglial activation and reduce the associated oxidative stress after SCI is critically important for developing effective therapeutic strategies.