63 studies on P21 curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
Independent certificate-of-analysis evidence from third-party labs — the data behind the studies. Updated as new COAs are verified. Read the full grey-market analysis →
| Manufacturer | Batches | Avg purity | |
|---|---|---|---|
| Modern Aminos | 2 | 98.75% | View COA → |
Recent certificates: #64980 (99.3%) · #57930 (99.17%) · #55913 (98.36%) · #40642 (98.745%)
Manufacturers with published third-party certificates of analysis for P21. Open a vendor to see every batch we've verified.
The discovery of **78b** and **78d** represents a significant step forward in targeting **KRAS-driven colorectal cancer**, offering potent pan-KRAS therapeutic candidates. These compounds address a critical unmet need…
This research significantly advances our understanding of AMBRA1's critical role in maintaining genomic stability by regulating CKI degradation, particularly `p21Waf1/Cip1`, during the S phase. **The findings suggest …
This study provides crucial insights into the molecular landscape of **wild-type (WT) KRAS colorectal cancer (CRC)**, a subtype often lacking targeted therapies. **Identifying cytoplasmic p27 localization as a feature…
This research fundamentally redefines our understanding of **KRAS** regulation, identifying **Mg2+-sensitive hotspots** that can be exploited for novel therapeutic strategies. By elucidating how **Mg2+** controls **KR…
This study establishes a molecular basis for classifying **TP53** variants of uncertain clinical significance, particularly the **R267W** mutation, as pathogenic. For clinicians and genetic counselors, this provides c…
This study fundamentally shifts our understanding of **p53**'s toxic effects, identifying specific cell cycle regulators (`p21`, `Gtse1`) as key mediators of its detrimental impact, rather than solely apoptosis-relate…
This research provides crucial mechanistic insights into nanoplastic toxicity, highlighting their capacity to induce inflammation and accelerate aging, even in young organisms, through the oral-gut microbiome axis. **…
This study identifies **p16INK4a** as a crucial mechanistic regulator of fibrosis progression, offering a novel therapeutic target for **Idiopathic Pulmonary Fibrosis (IPF)**. For peptide users and biohackers interest…
This research reveals a critical **KRAS**-induced `IFN` program that sensitizes **PDAC** cells to necroptosis, identifying a novel therapeutic vulnerability. For clinicians and researchers, this highlights a potential…
This research uncovers a novel epitranscriptomic mechanism governing **hPDLSC** senescence and chondrogenic differentiation, offering a new therapeutic target for **TMJOA**. **Targeting the YTHDC1-GADD45B-p53/p21 axis…
This study identifies tubular AMD1 as a critical metabolic checkpoint that maintains polyamine homeostasis, preventing `p53/p21`-dependent senescence and promoting adaptive repair after AKI. **Spermidine supplementati…
This research provides a critical mechanistic understanding of how **TiO2 nanoparticles** impair bone growth, specifically targeting chondrocyte function. For those concerned with environmental toxins and developmenta…
High 6PPD exposure is linked to unexplained miscarriage and placental senescence in humans and mice, via `BAZ1B`-mediated `P21` dysregulation.
This study significantly advances the understanding of **RASopathy** genetics in the Indian population, providing a crucial molecular and clinical profile. **Improved diagnostic yield via targeted gene panels** means …
**Genistein shows promise as an effective prophylactic agent against cutaneous radiation injuries and combined injuries.** This finding is highly relevant for developing pre-exposure countermeasures in high-risk scena…
This research identifies **GSTZ1** as a novel and promising complementary target to enhance the efficacy of **KRASG12C inhibitors** in **NSCLC**. For clinicians and biohackers, this suggests that combining **KRASG12C …
This study identifies `GDF15` as a critical mediator of epithelial cell senescence in **radiation-induced lung injury (RILI)**, operating through the `ERK1/2-p16` signaling pathway. **Targeting GDF15 or the ERK1/2-p16…
The discovery of **Peptide-1** offers a promising new avenue for targeting **KRASG12V**, a notoriously difficult-to-drug mutation in **colorectal cancer**. This peptide's selectivity for `KRASG12V` over other KRAS mut…
A novel therapeutic axis, `HDAC-p21-senescence`, is defined, offering a promising strategy to overcome acquired chemoresistance in **bladder cancer**. For clinicians and researchers, this suggests that combining epige…
**AL-VI10 offers a promising new strategy for combating vascular aging by targeting the `CD44-SIRT1-Nrf2` axis**, potentially leading to improved cardiovascular health. This discovery highlights a novel mechanism for …
This research identifies a novel, targetable mechanism for **rheumatoid arthritis** (RA) progression, shifting focus from traditional inflammatory pathways to metabolic reprogramming and protein modification. **Target…
**This study identifies a novel, selective therapeutic strategy for `ARID1A`-mutated cancers, a patient population currently lacking effective targeted treatments.** `WRN` inhibition offers a precise approach by explo…
This research offers a compelling new strategy for tackling **pancreatic ductal adenocarcinoma**, particularly for patients with `KRAS`-mutated tumors, by addressing the critical issue of therapeutic resistance. **Com…
This research identifies a novel mechanism where `SYVN1`-mediated `RASA1` degradation contributes to **COPD** inflammation, suggesting a potential new therapeutic target. **Modulating SYVN1 activity or stabilizing RAS…
Considering immunological age and pre-ART immune senescent status could personalize antiretroviral therapy strategies for **people living with HIV**. This study highlights that a patient's immune profile before starti…
This novel PNA-based method offers a significant leap in **accessible and precise genetic diagnostics**. By eliminating the need for complex thermal cycling equipment, it paves the way for **point-of-care SNP detectio…
This research provides crucial insights into how **early life stress fundamentally reshapes neuroimmune development**, particularly within the hypothalamus. For those interested in mental health and neurodevelopment, …
This study highlights **β-Ecdysterone as a potential therapeutic agent** for mitigating vascular aging and related cardiovascular diseases. For biohackers and individuals interested in longevity, β-Ecd's ability to co…
This pilot study provides early, hypothesis-generating evidence that systemic GLP-1RAs may exert a direct senomorphic effect on human skin, reducing cellular senescence markers like **p21**. For individuals interested…
This research provides a compelling hypothesis for why **KRas-mutated tumors** often resist immunotherapy, suggesting that **cathepsin B** activity in inflammatory microenvironments actively destroys critical neoepito…
The TN-derived P2-1 peptide specifically inhibits the HMGB1-pCTS-L inflammatory axis, preventing RAGE engagement and macrophage pyroptosis to ameliorate sepsis and RA.
Electroacupuncture at ST36 normalized blood glucose and improved glucose tolerance in acute hyperglycemia and prediabetes mice, enhancing pancreatic β-cell function.
This study highlights **electroacupuncture as a promising non-pharmacological intervention for Alzheimer's disease**, demonstrating its potential to improve cognitive function and restore hippocampal myelin integrity.…
Understanding AUF1's role in auditory hair cell senescence and inflammation opens new avenues for therapeutic intervention in **age-related hearing loss**. **Targeting AUF1 could offer a novel strategy for mitigating …
This research provides compelling preclinical evidence that **localized, high-dose magnesium injections could offer a novel, safe therapeutic strategy for cervical cancer**. By inducing a senescence-like state via the…
This research highlights a critical link between alcohol consumption and chemotherapy resistance in **colorectal cancer**, suggesting that **avoiding alcohol during oxaliplatin treatment could improve patient outcomes…
**Understanding the specific naïve CD4 T cell profiles in different HIV contexts could inform novel strategies to target viral reservoirs and prevent immune senescence.** This research suggests that the timing of ART …
Understanding the subcellular compartmentalization of **p21** offers a crucial new lens for developing targeted **cancer** therapies. Instead of broadly modulating p21 expression, future strategies could focus on mani…
This research significantly expands our understanding of neurofibromin's role beyond its well-established RAS-GAP activity, revealing novel **RAS-independent functions** mediated by its cooperation with SPRED1/2. For …
Liraglutide significantly upregulated GLP1R expression and activated cAMP/PKA signaling, inducing apoptosis and cell cycle arrest in MCF7 breast and PC-3 prostate cancer cells.
This study identifies OVCA2 as a novel oncogene and a promising therapeutic target in pediatric AML by elucidating its mechanism of CDKN1A regulation. Understanding this pathway could lead to the development of new ta…
This discovery represents a significant advancement in our fundamental understanding of DNA replication fidelity and the maintenance of genome stability. By identifying the Atad5 RFC-like complex as the primary PCNA u…
Accurate and transparent reporting of methodology, especially in data visualization, is absolutely critical for scientific reproducibility and interpretation. This correction ensures that future researchers interpreti…
The investigation revealed that TRPV1 activation significantly attenuated several critical markers of aortic aging in the atherosclerotic mouse model when compared to untreated control groups. Specifically, treated mi…
This research identifies p21+TREM2+ senescent macrophages as a critical and previously unrecognized driver of MASLD and associated inflammaging. The findings provide a novel understanding of how cellular senescence co…
This study provides compelling evidence that Humanin-G possesses significant neuroprotective capabilities in a preclinical model of retinal degeneration. The observed preservation of both retinal structure and functio…
The discovery of Plumbagin as a potent GGCT inhibitor opens new avenues for developing targeted cancer therapies. By inhibiting GGCT, Plumbagin could disrupt glutathione metabolism in cancer cells, making them more su…
This research fundamentally shifts our understanding of IGF-1's role in aging, proposing a biphasic model that moves beyond simple 'more is better' or 'less is better' paradigms. The identification of an IGF-1 senesce…
This research provides compelling evidence that cellular senescence in adipocytes directly contributes to insulin resistance, offering a novel mechanistic link between aging and metabolic disease. The findings suggest…
This research highlights `Meox1` as a novel and potentially critical driver of **hepatocellular carcinoma** progression, offering a new avenue for therapeutic intervention. **Targeting `Meox1` could represent a promis…
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