100 studies on Mots-c curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research highlights MOTS-c as a promising novel therapeutic candidate for age-related macular degeneration (AMD), addressing the critical need for treatments that target the underlying mitochondrial dysfunction. …
This pilot study positions MOTS-c as a promising novel biomarker for identifying chronic peritoneal dialysis patients at an elevated risk for sarcopenia. Early detection of sarcopenia through such a biomarker could fa…
This research is crucial for understanding the pleiotropic effects (multiple beneficial actions beyond the primary one) of GLP-1RAs and SGLT-2is in diabetes. By elucidating their impact on neurohumoral and mitochondri…
This research highlights MOTS-c as a promising novel therapeutic agent for preventing or treating CPB-induced acute lung injury. By promoting glycolysis through the AMPK-HIF-1α-PFKFB3 pathway, MOTS-c offers a unique m…
This review underscores the immense therapeutic potential of mitochondria-derived peptides as a novel class of agents for treating cardiovascular diseases. By directly targeting mitochondrial dysfunction, MDPs offer a…
Circulating PGC-1α and MOTS-c could serve as novel, non-invasive biomarkers for assessing mitochondrial health, predicting post-operative complications, and stratifying risk in AVR patients. This could enable earlier …
This research highlights MOTS-c's significant potential as a valuable new tool for the early diagnosis and improved management of Myocardial Infarction. Its ability to provide rapid and accurate diagnostic information…
This study provides compelling evidence that MOTS-c offers a robust protective effect against lung ischemia-reperfusion injury through a novel MYH9-dependent mechanism. The identification of MYH9 as a key mediator lin…
This study highlights MOTS-c as a promising therapeutic agent that can effectively combat diabetic liver fibrosis by mimicking the beneficial effects of exercise. Its ability to modulate key anti-fibrotic and antioxid…
The identification of these circulating mitochondrial biomarkers represents a significant advancement in the diagnostic landscape for Acute Coronary Syndrome. These novel markers could enable earlier and more accurate…
This research highlights MOTS-c as a promising novel therapeutic agent for allergic asthma, offering a unique approach by targeting a fundamental aspect of the disease: airway barrier dysfunction and epithelial apopto…
This research provides a critical mechanistic link between maternal obesity and the multigenerational inheritance of MASLD, highlighting mitochondrial dysfunction as a key driver. Understanding this pathway opens new …
This research highlights the significant potential of MOTS-c-modified peptide hydrogels as a novel therapeutic strategy for intervertebral disc degeneration. By enhancing the activity and survival of NP-MSCs, this app…
This study provides novel insights by identifying reduced MOTS-c levels as a potential characteristic of obstructive sleep apnea patients. Given MOTS-c's established role in metabolic health and cellular resilience, t…
The findings underscore the significant therapeutic potential of mitochondrial-derived peptides as a novel class of agents for preventing and treating vascular aging and associated cardiovascular diseases. By targetin…
These findings highlight MOTS-c as a highly promising therapeutic candidate for treating diabetic cardiomyopathy by directly addressing the underlying mitochondrial dysfunction. The ability of MOTS-c to restore fundam…
This research is significant because it suggests that repeated heat stress could serve as a non-pharmacological intervention to influence metabolic and muscular health, particularly during periods of muscle disuse or …
This review significantly advances our understanding of Parkinson's disease by highlighting the previously underappreciated role of mitochondria-derived microproteins (MDPs) as key players in its pathogenesis. The fin…
This research highlights MOTS-c as a promising therapeutic candidate for mitigating sepsis-associated brain injury by directly targeting the blood-brain barrier. The ability of MOTS-c to preserve BBB integrity and red…
This research highlights the immense potential of a novel multi-biomarker panel to revolutionize prostate disease diagnosis and risk stratification. By combining Humanin, GAS5, miR-21, and miR-103, clinicians could ac…
These findings are highly significant as they identify MOTS-c as a critical regulator of pancreatic islet cell senescence, a process implicated in both type 1 and type 2 diabetes. The ability of MOTS-c to reduce senes…
This research highlights the critical role of muscle-fat crosstalk in maintaining metabolic health during aging and provides compelling evidence that its decline can be pharmacologically targeted. The findings suggest…
This research highlights MOTS-c as a promising therapeutic candidate for osteoarthritis, offering a novel approach by simultaneously targeting mitochondrial health, reducing inflammatory cell death, and activating pro…
This comprehensive review highlights MOTS-c as a highly promising therapeutic candidate for Type 2 Diabetes Mellitus (T2DM), offering a multi-pronged approach to combat both metabolic dysfunction and severe cardiac co…
This research highlights MOTS-c as a highly promising therapeutic candidate for intrauterine growth restriction (IUGR), a condition currently plagued by limited effective treatment options. By demonstrating its abilit…
This research highlights the potential of Humanin, Mots-c, and telomere length as novel, non-invasive biomarkers for Alzheimer's disease. Identifying such biomarkers could pave the way for earlier and more accurate di…
This groundbreaking research suggests that circulating MOTS-c could serve as a powerful new diagnostic and prognostic biomarker for Acute Coronary Syndrome and Major Cardiac Events. The ability to identify patients at…
This review establishes a crucial link between mitochondrial-derived microproteins and the pathogenesis of both cancer and neurodegenerative diseases, offering a novel perspective on disease etiology. By identifying c…
This research positions MOTS-c as a highly promising complementary biomarker for assessing treatment response in Multiple Myeloma, offering a novel avenue for patient monitoring. Its dynamic changes could enable earli…
This research highlights MOTS-c as a potent activator of muscle mitochondrial function, offering a novel therapeutic strategy for conditions characterized by mitochondrial dysfunction and muscle decline. By improving …
This review significantly advances our understanding of mitochondria-derived peptides (MDPs) as critical regulators of hepatic metabolism and potential therapeutic agents. The identification of MDPs like MOTS-c and Hu…
These findings suggest that elevated MOTS-c could serve as a novel biomarker for obesity-associated metabolic dysregulation, potentially identifying individuals at higher risk for complications. The persistence of hig…
This review highlights a significant untapped area of research with profound implications for understanding and treating lung diseases. Given the established roles of MDPs in other complex diseases, their investigatio…
This study provides compelling evidence that exogenous MOTS-c can effectively mitigate myocardial ischemia-reperfusion injury by preserving cardiac function, reducing infarct size, and combating oxidative stress. Give…
This research provides compelling evidence that MOTS-c could serve as a novel and effective therapeutic agent for preventing or treating cardiac dysfunction associated with high-altitude exposure. By actively promotin…
This research highlights MOTS-c as a potential biomarker and therapeutic target for Polycystic Ovary Syndrome (PCOS). The strong association between reduced MOTS-c and mitochondrial dysfunction suggests that restoring…
This research highlights MOTS-c as a promising novel therapeutic candidate for Autism Spectrum Disorder, potentially addressing both behavioral symptoms and underlying neurobiological deficits. The ability of MOTS-c t…
This research provides compelling evidence that MOTS-c and humanin could represent novel therapeutic agents for preventing or treating muscle atrophy, particularly in contexts involving corticosteroid use or other cat…
This research highlights MOTS-c as a promising therapeutic candidate for preventing or treating acute liver injury caused by acetaminophen overdose. Its ability to modulate the MAPK signaling pathway and reduce both n…
This research is highly significant as it identifies MOTS-c as a promising therapeutic candidate for preventing or treating bronchopulmonary dysplasia, a major cause of morbidity in premature infants. By activating th…
This detailed chemical profile is crucial for the unambiguous identification and characterization of MOTS-c in research and development. Accurate chemical identification is the bedrock for all subsequent experimental …
This comprehensive screening program holds immense potential to revolutionize early intervention strategies for newborn hearing loss. By identifying genetic causes early, clinicians can offer more personalized prognos…
This research powerfully highlights the graviola oil extract's potential as a natural, multi-faceted supplement for significantly enhancing livestock productivity and overall health. By effectively improving fattening…
This research highlights a novel role for MOTS-c in modulating adrenal gland metabolism, specifically by enhancing mitochondrial function and energy production without directly impacting steroid hormone synthesis. Thi…