105 studies on IGF-1 curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This Phase 4 study is significant because it investigates a sequential therapy approach for Thyroid Associated Ophthalmopathies (TAO), a debilitating condition often resistant to current treatments. IBI311, as an anti…
This research is critical for understanding the molecular mechanisms behind skin aging and its response to environmental stressors like UVB. If Insulin-Like Growth Factor 1 proves effective in modulating gene expressi…
These findings highlight capsaicin as a promising therapeutic candidate for managing insulin resistance-induced prostatic hyperplasia, offering a natural compound approach to a widespread health issue. By modulating I…
The findings suggest that IGF-1 supplementation could be a safe and effective strategy for preventing severe ROP in extremely premature infants, potentially mitigating the devastating visual outcomes associated with t…
This research highlights a novel mechanistic link between Aβ pathology, IGF1R nuclear signaling, and aberrant cell cycle re-entry in Alzheimer's disease. Understanding this pathway could open new avenues for therapeut…
This research provides crucial mechanistic insights into how Electrical Muscle Stimulation (EMS) combats denervated muscle atrophy following brachial plexus injury. By demonstrating the involvement of the Cav1.1-Ca2+-…
If GHRH were found to be effective, this research could pave the way for a novel therapeutic strategy to address age-related sleep disturbances, a widespread issue affecting millions. Successfully augmenting the GH-IG…
These findings suggest that GHRH therapy could represent a novel therapeutic strategy for improving cardiac function and quality of life in older adults with congestive heart failure and reduced growth hormone effect.…
This study provides compelling evidence that tesamorelin could be a highly effective pharmacological intervention for MASLD, addressing a critical unmet medical need. The significant reduction in liver fat observed su…
The intent behind this study highlights a critical challenge in endocrinology: the potential for significant inter-assay variability to compromise the accurate diagnosis and management of Growth Hormone (GH) disorders…
This foundational Phase 1 study is critical because it provides essential data on how Tesamorelin behaves in HIV positive patients, a population with unique metabolic considerations. The successful characterization of…
This research highlights tesamorelin's potential as a targeted therapeutic option for managing HIV lipodystrophy, offering more than just cosmetic benefits. The significant reduction in visceral fat, coupled with impr…
The withdrawal of this study means a significant opportunity was missed to explore a potential therapeutic avenue for muscle wasting in advanced CKD. Sarcopenia in CKD patients is a major predictor of morbidity and mo…
This research highlights hUCB-MSCs as a promising therapeutic strategy for mitigating core symptoms of Autism Spectrum Disorder. The identification of the IGF-1/Akt signaling pathway as a key mechanism provides valuab…
This scoping review provides a crucial roadmap for future research by consolidating the diverse landscape of peptides being explored for skeletal muscle wasting. It highlights the significant therapeutic potential of …
This research highlights the significant potential of GHRP-6 as a functional feed additive in aquaculture, offering a novel strategy to enhance both growth performance and disease resistance in farmed fish. The abilit…
This study delivers a significantly enhanced and highly reliable analytical tool that will empower anti-doping laboratories globally. The substantial improvements in sensitivity and specificity will strengthen the abi…
This study provides crucial preclinical evidence that GHRP-2 can effectively overcome established negative feedback to restore physiological pulsatile growth hormone secretion, rather than simply inducing a general in…
This research highlights the potential for a less invasive and more convenient diagnostic approach for Adult Growth Hormone Deficiency. The strong discriminative power of urinary GH and IGF-SDS could significantly red…
This study provides compelling evidence that the combination of GHRP-2 and Cysteamine can synergistically enhance growth performance and muscle development in yaks with growth retardation. This could have significant …
The findings from this research are highly significant as this new panel of genetic and protein biomarkers offers a substantially more robust and prolonged detection window for identifying growth hormone abuse. This e…
This research highlights RECK as a novel and potentially significant regulator within the GH/IGF-1 axis, offering a deeper understanding of growth and metabolic control. Identifying RECK's role could open new avenues …
This review underscores the critical role of endocrine imbalances in the pathophysiology of cachexia and highlights the therapeutic potential of steroid pharmacotherapy. By systematically evaluating the evidence, it p…
These findings strongly suggest that GHRH antagonists could be a potent new therapeutic strategy for advanced prostate cancer by simultaneously inhibiting tumor growth and its ability to spread. The observed reduction…
This study's findings are significant as they highlight the potential of Growth Hormone Secretagogues (GHS) to effectively elevate IGF-1 levels in hypogonadal men, a population often struggling with associated metabol…
These findings highlight GHRH receptor antagonists as a promising therapeutic strategy for prostate cancer by targeting multiple pathways involved in tumor growth and angiogenesis. The ability to inhibit both cell pro…
This study highlights that MIA-602 represents a novel, targeted therapeutic approach for Acute Myeloid Leukemia, by effectively antagonizing the GHRH pathway. Given the significant unmet need for more effective and le…
This finding is significant because it suggests that systemic administration of GH or GH secretagogues may not directly influence GH/IGF-1 signaling within the brain, at least not via increased CSF concentrations. Thi…
This research highlights a novel mechanism by which MK-677 may influence metabolic pathways, specifically by altering the tightly regulated relationship between leptin and body fat. Understanding this discrepancy is c…
This review significantly expanded the understanding of GHS pharmacology, moving beyond their traditional role in GH deficiency. The identification of diverse non-endocrine actions, such as effects on appetite, metabo…
The findings suggest that GHS represent a promising therapeutic strategy for combating age-related decline in GH and IGF-1, potentially improving body composition and overall vitality in older adults. By stimulating e…
This review underscores the critical role of the GH/IGF-1 axis in maintaining bone health and highlights the therapeutic potential of both GH and GHSs for bone disorders. The development of GHSs, which stimulate the b…
The administration of MK-677 led to significant and sustained increases in overall growth hormone (GH) secretion. Specifically, the study observed pronounced elevations in both the 22 kDa and 20 kDa GH isoforms, which…
This study provides compelling evidence that MK-0677, an oral growth hormone secretagogue, can significantly enhance recovery outcomes in elderly patients following hip fracture surgery. The observed improvements in l…
The development of GHSs represents a paradigm shift in treating conditions associated with GH deficiency or catabolic states. These compounds offer a non-invasive, orally active alternative to recombinant GH, potentia…
This research strongly suggests that targeting the GH/IGF-1 axis could be a powerful strategy to combat age-related cardiovascular decline and improve vascular health. By restoring endothelial progenitor cell (EPC) fu…
This research highlights the potential of an oral ghrelin mimetic as a therapeutic strategy to combat age-related muscle loss and improve physical function in older adults. The oral route of administration offers a si…
This study provides compelling evidence that MK-0677, an oral ghrelin receptor agonist, can effectively increase IGF-1 levels in hemodialysis patients. This is a critical step towards addressing the IGF-1 deficiency o…
This comprehensive review underscores the therapeutic promise of GHS for conditions characterized by GH deficiency or age-related decline, such as sarcopenia and frailty, by effectively stimulating endogenous GH relea…
This research strongly supports the potential of oral MK-677 as an effective agent for stimulating growth hormone release and promoting somatic growth. The significant increases in body weight, linear growth, and IGF-…
This research provides crucial data on the metabolic fate and elimination profile of MK-0677 in horses, which is vital for anti-doping efforts. The identification of long-lived urinary metabolites significantly extend…
This case report provides crucial, albeit preliminary, human data on the combined effects of LGD-4033 and MK-677, highlighting their potent impact on body composition and endocrine function. The observed anabolic effe…
This study highlights a critical paradox in diabetes: GH hypersecretion coexisting with peripheral GH receptor resistance. This finding suggests that the body attempts to compensate for impaired GH signaling by increa…
This study unequivocally highlights the severe public health risks associated with the use of unregulated black market growth-promoting products. Consumers are frequently exposed to mislabeled, contaminated, or entire…
This study conclusively demonstrates the efficacy of CJC-1295 as a potent, long-acting stimulator of the GH/IGF-1 axis, offering a significant advancement over traditional GHRH therapies. Its ability to provide sustai…
This study demonstrates that CJC-1295 is a highly effective long-acting GHRH analog capable of restoring normal growth in a severe model of GHRH deficiency. The ability to achieve significant growth normalization with…
These findings provide a deeper understanding of the systemic effects of GH/IGF-1 axis activation beyond just GH and IGF-1 levels, revealing a complex interplay with various physiological pathways. The observed change…
This preclinical study provides compelling evidence that GHRP-6 holds significant promise as a therapeutic agent for combating severe muscle wasting conditions like cancer cachexia. Its demonstrated ability to stimula…
The ability of Sermorelin to stimulate the body's natural GH production offers a significant advantage over direct GH replacement, potentially reducing side effects and maintaining physiological feedback loops. This a…