MOTS-c Peptide Prevents Muscle Atrophy and Boosts Glucose Uptake via CK2 Activation
MOTS-c modulates skeletal muscle function by directly binding and activating CK2.
Background
MOTS-c is a fascinating mitochondrial microprotein that has garnered significant attention for its established role in improving overall metabolism and cellular energy homeostasis. Despite its recognized metabolic benefits, the precise molecular targets and intricate mechanisms by which MOTS-c exerts its beneficial effects, particularly within the context of skeletal muscle function, have remained largely elusive and poorly understood until now.