Topical Aminocaproic Acid Explored for Rosacea Inflammation Treatment

Rosacea is a prevalent, chronic inflammatory skin condition characterized by facial redness and papules, largely driven by the dysregulation of the innate immune system. A key mechanism involves overactive Kallikrein 5 (KLK5) serine protease, which abnormally activates LL-37 cathelicidin peptide, a potent pro-inflammatory mediator in the skin. This study aimed to investigate if topical aminocaproic acid (ACA) could specifically modulate this critical inflammatory cascade by inhibiting KLK5 activity and subsequent LL-37 production in rosacea patients.