BTK Inhibition Significantly Reduces Bladder Pain and Inflammation in an IC/BPS Model
Role of Bruton's Tyrosine Kinase in mast cell driven urothelial barrier injury in an LL-37 induced model of interstitial cystitis.
Study Design
Population
The study investigated an IC/BPS model, but the specific animal model or cell line and sample size (n) are not provided in the digest.
Intervention
The intervention involved BTK inhibition, but the specific compound, dose, route, and duration are not specified in the digest.
Comparator
The digest does not specify a comparator group (e.g., vehicle, sham, or control) for the BTK inhibition.
Outcome
The primary outcome measured was the reduction of bladder pain and inflammation in the IC/BPS model.
Abstract
Role of Bruton's Tyrosine Kinase in mast cell driven urothelial barrier injury in an LL-37 induced model of interstitial cystitis.
Authors: Wang G, Li BS, Chu JY, Chen X, Yang TX, Fang KW, Li JM
Journal: Scientific reports (2026)
DOI: 10.1…