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Oxytocin 2026-02-09 ClinicalTrials

Dog Adoption and Training Program Explored for PTSD, Stress, and Brain Changes in Veterans

Impact of Dog Adoption and Training in Veterans With Post-traumatic Stress Symptoms and/or Other Mental Health Conditions

Background

Post-traumatic stress disorder (PTSD) is a debilitating condition affecting many veterans, characterized by intrusive thoughts, avoidance, negative alterations in cognition and mood, and hyperarousal. Current treatments, primarily psychotherapy and pharmacotherapy, can be effective but often have limitations, including treatment resistance, side effects, and accessibility issues. There's a growing interest in complementary and alternative therapies that can address both the psychological and physiological manifestations of PTSD, such as chronic stress and systemic inflammation. Animal-assisted therapy (AAT), particularly involving dogs, has shown promise in improving mental well-being, reducing stress markers, and fostering social connection, potentially by modulating neuroendocrine systems like oxytocin and impacting brain regions involved in emotional regulation. This study aims to explore this gap.

Study Design

This single-arm study investigates the impact of a dog adoption and training program in veterans diagnosed with self-reported post-traumatic stress symptoms and/or other mental health conditions. Participants will engage in eight one-hour professional dog training sessions over a 10-week period, focusing on positive reinforcement and building the human-animal bond. Throughout the study, participants will visit the clinical research unit four times for comprehensive data collection. Primary endpoints include changes in posttraumatic stress symptoms (measured by validated questionnaires), stress levels (via physiological markers and self-report), and overall psychosocial health. Additionally, researchers will assess biological markers such as systemic inflammation (e.g., cytokine levels via ELISA), circulating oxytocin concentrations, and structural/functional changes in specific brain regions using MRI and resting-state fMRI. The program's feasibility and participant engagement will also be evaluated.

Results

This record describes a study protocol; no findings or results are available at this time as the study is ongoing.

Why It Matters

If this dog adoption and training program demonstrates efficacy, it could establish a powerful, non-pharmacological, and potentially life-changing intervention for veterans struggling with PTSD and related mental health conditions. This approach offers a holistic intervention that addresses not only psychological symptoms but also physiological markers like stress and inflammation, and even brain health. The integration of a companion animal could provide sustained emotional support, promote physical activity, and foster social engagement, which are often challenging for individuals with PTSD. This research could pave the way for dog-assisted therapy to become a recognized and accessible complementary protocol within veteran healthcare systems, offering a unique blend of companionship, purpose, and therapeutic engagement that current treatments may not fully provide. It highlights the potential for personalized, non-drug interventions to significantly improve quality of life.


Source: clinicaltrials:NCT07542431 · Ingested 2026-06-02 · Digest: gemini-2.5-flash