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Oxytocin 2026-09 ClinicalTrials

Antenatal breastmilk expression from week 28 aims to ensure early milk access and assess safety in high-risk pregnancies

Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm Birth

Background

Preterm birth poses significant health challenges for infants, often requiring extended neonatal intensive care. Early access to mother's own milk (MOM) is crucial for their development, providing immunological benefits and reducing risks like necrotizing enterocolitis. However, mothers of preterm infants frequently face difficulties initiating and sustaining lactation due to stress, infant separation, and medical complications. Current strategies often involve donor milk or formula, highlighting a gap in ensuring timely and sufficient supply of MOM immediately post-birth for these vulnerable infants. Antenatal interventions are explored to bridge this critical period.

Study Design

This randomized controlled study aims to enroll pregnant women at high risk of preterm birth. Participants will undergo antenatal breastmilk expression (aBME) starting from week 28 of gestation. The study design includes a comparison of colostrum collected during pregnancy with colostrum after birth, assessment of women's confidence in breastfeeding, and measurement of oxytocin levels during aBME and active labor (in a control group without aBME). The primary objective is to evaluate the safety and effectiveness of aBME in ensuring early access to mother's own milk.

Results

This study is designed to investigate, rather than report findings. The researchers aim to determine if antenatal breastmilk expression (aBME) from week 28 in high-risk pregnancies is a safe and effective method to ensure early access to mother's own milk. They will also analyze and compare colostrum composition from pregnancy with colostrum collected after birth. Furthermore, the study will assess women's confidence in breastfeeding and the establishment of breastfeeding, alongside measuring oxytocin levels during aBME and active labor in a control group. No specific results or numerical data are presented in the abstract, as it outlines the study's objectives and methodology.

Why It Matters

Implementing antenatal breastmilk expression (aBME) could significantly improve early nutritional support for preterm infants, a critical factor for their survival and long-term health. If proven safe and effective, this approach could empower mothers at high risk of preterm birth by providing a proactive strategy to establish their milk supply before delivery, reducing reliance on donor milk or formula. This could lead to a standardized protocol for high-risk pregnancies, potentially impacting clinical guidelines for perinatal care. Understanding the impact on oxytocin levels might also inform future interventions related to labor induction or uterine contractility.


Source: clinicaltrials:NCT07191366 · Ingested 2026-07-07 · Digest: gemini-2.5-flash