Intranasal Oxytocin Hypothesized to Enhance Trust Towards Both Humans and Dogs in Therapy Settings

Oxytocin is a crucial neuroendocrine mechanism implicated in social bonding and positive health outcomes associated with dog ownership, particularly through human-dog interactions. Its role in general human social behavior is well-established, mediating trust and attachment. However, the specific function of oxytocin in human-animal interaction and the efficacy of Animal-Assisted Interventions (AAI) remains largely undefined. This significant research gap necessitates high-quality studies to elucidate the underlying neuroendocrine mechanisms of AAI. Understanding if intranasally administered oxytocin can enhance trust towards both humans and animals could profoundly advance knowledge about AAI, especially since canine-assisted therapy has shown promise in reducing depression and improving emotional stability by increasing endogenous oxytocin levels.