Nitroglycerin Hypothesized to More Effectively Relax Oxytocin-Desensitized Human Myometrium

Achieving rapid uterine relaxation is invaluable in acute obstetric emergency settings for maternal and fetal well-being. Oxytocin is critical for myometrial contraction via the oxytocin receptor (OTR), but prolonged exposure leads to OTR desensitization, necessitating higher doses for labor augmentation. While nitroglycerin is a commonly used agent for rapid uterine relaxation, its efficacy on desensitized myometrium and the subsequent re-establishment of tone with oxytocin remain unexamined. This study addresses this critical gap in understanding uterine pharmacodynamics.