Oral Misoprostol Compared to Vaginal Misoprostol for Non-Inferiority in Labor Induction Time

Pharmacologic cervical ripening and labor induction are critical obstetric interventions, often necessitated by various maternal or fetal indications. While misoprostol, a synthetic prostaglandin E1 analog, is widely utilized for its uterotonic and cervic-ripening properties, its optimal administration route, dosage, and frequency remain subjects of ongoing research. Vaginal administration is common but can be associated with variable systemic absorption and patient discomfort. Exploring oral administration offers potential advantages in terms of ease of use, patient preference, and potentially more predictable pharmacokinetics, addressing current gaps in optimizing patient experience and safety during this crucial phase of childbirth.