Intranasal Oxytocin Investigated to Normalize Trust and Neural Processing in Borderline Personality Disorder

Borderline Personality Disorder (BPD) is a complex mental health condition marked by severe emotional dysregulation, impulsivity, and unstable interpersonal relationships, often leading to profound difficulties with trust. Existing evidence suggests a significant difference in trust-related behavior and oxytocin (OXT) levels between BPD patients and healthy controls, indicating a potential biological underpinning for these social deficits. Current therapeutic approaches often struggle to fully address these core trust impairments. Oxytocin, a neuropeptide known for its role in social bonding, trust, and empathy, presents a promising target for modulating these critical behaviors in BPD.