Single-cell profiling reveals IL6-centered immunometabolic circuit driving multiple myeloma progression
Single-cell and functional profiling identifies an IL6-centered immunometabolic communication circuit in multiple myeloma.
Background
Multiple myeloma (MM) is an incurable plasma cell malignancy where malignant cells thrive within a specialized bone marrow microenvironment, leading to relapse and drug resistance. This complex ecosystem involves immune dysfunction, inflammatory signaling, and metabolic stress, reinforcing tumor survival. Current therapies often fall short due to this intricate interplay. Understanding the compartment-level communication within this tumor microenvironment is crucial for identifying novel therapeutic targets beyond direct tumor cell killing.