Short-chain fatty acid delivery site dictates systemic concentrations, GLP-1/PYY release, and appetite in humans
Small intestinal versus colonic short-chain fatty acid delivery drives distinct systemic concentrations and endocrine responses in humans: a randomized, crossover trial.
Abstract
Colonic SCFA delivery boosted PYY, while small intestinal delivery increased GLP-1, systemic SCFA, and appetite suppression in healthy adults.