Vitamin C Enhances Human Allospecific Induced Treg Stability and Function via FOXP3 Demethylation
Increased phenotypic and functional stability of human allospecific induced Tregs is associated with Vitamin C-mediated FOXP3 TSDR demethylation.
Abstract
Vitamin C supplementation during expansion significantly improved human induced Treg (iTreg) phenotypic and functional stability, reducing FOXP3 TSDR methylation from 85.9% to 43.5%.