Cholesterol-responsive NFE2L1-INSIG1 interaction sustains VLDL secretion, attenuating MASH in mice.
Cholesterol-responsive NFE2L1-INSIG1 interaction controls VLDL secretion and metabolic dysfunction-associated steatohepatitis pathogenesis in mice.
Abstract
NFE2L1-INSIG1 interaction, strengthened by cholesterol, promotes INSIG1 degradation, activating SREBP1 to sustain VLDL secretion and attenuate MASH in mice.