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2026-07-08 PubMed

TSPNL improves senescent cognition by modulating microglial NLRP3/Caspase-1 axis and gut microbiota

Total Saponins of Panax Notoginseng Leaves Modulate the "Microglial-NLRP3/Caspase-1" Axis associated with Gut Microbial/SCFAs Alterations: Correlative Insights into Cognitive Improvement in Senescence.

Abstract

Total Saponins of Panax Notoginseng Leaves (TSPNL) improved learning and cognition in senescent rats, reducing hippocampal neuroinflammation via the NLRP3/Caspase-1 axis and altering gut microbiota.


Source: pubmed:42418046 · Ingested 2026-07-08 · Digest: gemini-2.5-flash