Zebrafish GCGRa and GCGRb isoforms distinctly regulate lipid and glucose metabolism; GCGRb responds to glucagon and GLP-1.
Targeting glucagon signaling in metabolic disorders, functional insights from zebrafish receptor knockouts.
Abstract
Zebrafish glucagon receptor isoforms, GCGRa and GCGRb, distinctly regulate lipid and glucose metabolism; GCGRb uniquely responds to both glucagon and GLP-1.