Blueberry Anthocyanins Ameliorate Radiation-Induced Intestinal Injury by Modulating Gut Microbiota in Mice

Radiation-induced intestinal injury (RIII) is a severe and prevalent consequence of radiation therapy for abdominal or pelvic tumors, significantly impacting treatment outcomes and patient quality of life. Current Western medicine approaches, including medical drug therapy, hyperbaric oxygen therapy, and nutritional support, primarily offer symptomatic management but fall far short of achieving ideal therapeutic outcomes. Blueberry anthocyanins (BA) are being investigated as a potential novel strategy due to their known anticancer, potent anti-inflammatory, antioxidant, and anti-radiation properties, addressing an unmet need in RIII management.