GLP-1 L-cells secrete anti-inflammatory GILZ protein, significantly reduced in active ulcerative colitis.
Glucocorticoid-induced Leucine Zipper (GILZ) is a novel secreted protein by intestinal L-cells and is dysregulated during active ulcerative colitis.
Background
The Glucocorticoid-Induced Leucine Zipper (GILZ) is a key mediator of the anti-inflammatory effects of glucocorticoids, primarily within the immune system. Recent evidence has implicated GILZ as a secretive protein in goblet cells, with reduced expression linked to active Inflammatory Bowel Disease (IBD), suggesting a role in intestinal cell homeostasis. While GILZ was also detected in enteroendocrine cells (EECs), its specific role and expression profile within these cells remained undefined. This study addresses this gap, focusing on ulcerative colitis (UC), a chronic inflammatory condition of the colon, to understand GILZ's secretive function and its dysregulation during inflammation.