Macrocyclic Peptides Targeting CHD4-GATAD2A Interaction Reveal CHD4 as NuRD Complex Hub, Guiding Beta-Hemoglobinopathy Therapy
Macrocycle screening against the C-terminal region of CHD4 uncovers its role as an interaction hub in the formation of the nucleosome remodeling and deacetylase complex.
Abstract
Small macrocyclic peptides inhibited CHD4-GATAD2A interaction, revealing CHD4 as a critical NuRD complex hub and a therapeutic target for beta-hemoglobinopathies.