Optimizing Insulin Dosing for Exercise in Type 1 Diabetes Patients
Effects of a 50% versus 100% pre-prandial insulin bolus reduction to improve glycemic safety during postprandial continuous and intermittent exercise in adults with type 1 diabetes treated with multiple daily injections.
Background
Individuals with type 1 diabetes (T1D) face challenges managing blood glucose during physical activity, often experiencing hypoglycemia (low blood sugar) due to insulin action combined with exercise-induced glucose uptake. Current guidelines recommend reducing pre-meal insulin boluses before exercise, but the optimal reduction strategy for different exercise types remains unclear. This study specifically addresses whether a 50% versus a 100% pre-prandial insulin bolus reduction is safer and more effective for glycemic control during postprandial continuous and intermittent exercise.
Study Design
Population
Patients with type 1 diabetes (T1D) who engage in physical activity.
Intervention
A 50% reduction in pre-prandial insulin bolus before exercise.
Comparator
A 100% reduction in pre-prandial insulin bolus before exercise.
Outcome
Glycemic control and safety (hypoglycemia incidence) during postprandial continuous and intermittent exercise.