Novel Peptide KPEP-1 Accelerates Diabetic Wound Healing by Boosting Keratinocyte Proliferation.

Diabetic foot ulcers and other chronic non-healing wounds are severe complications of diabetes mellitus, often leading to amputations. A primary impediment to healing is impaired proliferation and migration of keratinocytes, crucial for re-epithelialization, alongside persistent inflammation and poor angiogenesis. Existing therapies often fall short. This research specifically addresses the critical knowledge gap by investigating novel multidimensional regulatory mechanisms and evaluating a targeted peptide-based strategy to restore robust keratinocyte proliferation and improve overall wound closure in diabetic conditions.