Multi-Receptor Agonists and Next-Gen Modulators Reshape Obesity Drug Development Landscape

Obesity remains a formidable global health challenge, significantly increasing the risk of severe comorbidities such as type 2 diabetes, cardiovascular disease, and certain cancers. While current pharmacotherapies offer some relief, many patients struggle to achieve and maintain substantial weight loss, often encountering limitations in efficacy or tolerability. This comprehensive review critically examines the emerging landscape of multi-receptor agonists and next-generation metabolic modulators, aiming to synthesize their potential to overcome the shortcomings of existing treatments and redefine the future of obesity management.