Low-level laser therapy (LLLT) accelerates orthodontic canine retraction more effectively than platelet-rich fibrin (PRF).

Orthodontic tooth movement (OTM), particularly canine retraction, is a common but often prolonged process. Traditional methods can be slow, leading to extended treatment times and potential patient discomfort. Accelerating OTM safely and effectively is a significant clinical goal. Both platelet-rich fibrin (PRF) and low-level laser therapy (LLLT) are explored for their regenerative and anti-inflammatory properties, with PRF leveraging growth factors from concentrated platelets and LLLT utilizing photobiomodulation to enhance cellular activity and modulate interleukin-1 beta (IL-1β), a key inflammatory cytokine in bone remodeling. This study investigates their comparative efficacy.