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retatrutide gip agonist review 2026-04-03 PubMed

Modern Strategies Combat Obesity: Understanding Pathophysiology and New Treatments

Obesity: Clinical Impact, Pathophysiology, Complications, and Modern Innovations in Therapeutic Strategies.

Background

Obesity is a pervasive global health challenge, affecting hundreds of millions worldwide and significantly increasing the risk of numerous severe comorbidities such as type 2 diabetes, cardiovascular disease (including hypertension and atherosclerosis), non-alcoholic fatty liver disease (NAFLD), sleep apnea, and certain cancers. Despite its widespread impact, the complex interplay of genetic predispositions, environmental factors, and lifestyle choices in driving obesity's intricate pathophysiology, and the optimal integration of novel, highly effective therapeutic strategies, remains a critical area for comprehensive understanding and clinical advancement in modern medicine.


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Source: pubmed:40843857 · Ingested 2026-04-03 · Digest: gemini-2.5-flash