Unimolecular Polypharmacology: The Future of Weight Loss Blockbuster Drugs

The global epidemic of obesity and related metabolic disorders presents a significant public health challenge, driving an urgent need for highly effective and safe therapeutic interventions. While current weight loss medications have shown promise, many face limitations in efficacy or tolerability, hindering their widespread impact. This review explores the critical role of unimolecular polypharmacology in overcoming these hurdles and developing next-generation weight loss treatments.