Perilla frutescens-derived vesicles and postbiotics synergistically restore skin barrier, reduce inflammation, and rebalance redox in atopic dermatitis.

Atopic dermatitis (AD) is a chronic inflammatory skin disease marked by profound skin barrier dysfunction and complex immune dysregulation, primarily driven by Th2-polarized responses. Patients often exhibit skin microbiome dysbiosis, including S. aureus overcolonization and reduced beneficial commensals like Staphylococcus epidermidis. Conventional treatments, such as topical corticosteroids, offer symptomatic relief but carry long-term side effects, highlighting the need for safer, multi-targeted adjunctive therapies that address barrier integrity, inflammation, and microbial balance.

This preclinical study investigated the synergistic effects of Perilla frutescens-Derived Effector Vesicles (PDEVs) and postbiotics as a triple-action strategy for atopic dermatitis. While specific model details (species, n, dose, route, duration) are not provided in the abstract, the research assessed the intervention's impact on key AD markers. Primary endpoints included evaluating skin barrier integrity via histopathological evaluation, systemic inflammation by measuring serum IgE levels, and redox balance through superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and nitric oxide (NO) activities.

The combined treatment with Perilla frutescens-Derived Effector Vesicles and postbiotics demonstrated significant therapeutic effects in the preclinical model of atopic dermatitis. Treatment notably reduced serum IgE levels, a key biomarker for allergic inflammation, and effectively restored the body's redox balance. This restoration was evidenced by a significant increase in antioxidant enzyme activities, specifically superoxide dismutase (SOD) and catalase (CAT). Simultaneously, the intervention led to a decrease in pro-oxidant markers, with malondialdehyde (MDA) and nitric oxide (NO) levels being reduced.

Histopathological evaluation further confirmed the restoration of skin barrier integrity, indicating a direct structural improvement in the affected skin.