112 studies on LL-37 curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study provides robust evidence supporting Ivermectin's direct anti-inflammatory properties in addition to its known antiparasitic effects, offering a more complete understanding of its therapeutic benefits in ros…
Understanding the balance between the antimicrobial benefits of mouthwashes and their potential impact on the body's natural defenses is crucial for oral health. If widely used mouthwashes significantly reduce hBD2 an…
This research holds profound implications for optimizing COPD treatment strategies, particularly for patients living in areas with high air pollution. If inhaled corticosteroids are found to increase vulnerability to …
This research holds significant implications for understanding vitamin D physiology and optimizing supplementation protocols for populations living in environments with minimal sun exposure. Should the findings demons…
Understanding the interplay between LL-37, Vitamin D3, and smoking in the context of chronic periodontitis is vital for developing targeted therapies. If significant findings had been reported, they could have reveale…
This research identifies LAPTM5 as a novel and critical regulator of the STING pathway in the context of rosacea, offering a new perspective on the disease's pathogenesis. The findings suggest that targeting LAPTM5 co…
This research highlights the significant potential of LL-37-Mod1 as a novel therapeutic agent against the growing threat of multidrug-resistant bacterial infections. Its rapid bactericidal action and membrane-disrupti…
This research highlights the significant potential of human adipose-derived stem cells (hADSCs) as a novel therapeutic strategy against antibiotic-resistant infections, particularly those resistant to innate immune de…
This study provides compelling evidence that poor vitamin D status is strongly associated with worse clinical outcomes in patients with diabetic foot infections. The significant correlation with larger wounds, increas…
This study provides compelling evidence that long-pulsed 1064-nm Nd:YAG laser therapy can effectively alleviate rosacea symptoms by addressing a fundamental underlying pathology: lymphatic vessel dysfunction. By impro…
This comprehensive review underscores the transformative potential of integrating AMPs and advanced regenerative medicine techniques into clinical wound management. The findings suggest these innovative approaches cou…
The identification of specific resistance genes is paramount for understanding the evolving landscape of antibiotic resistance. This knowledge is critical for developing rapid diagnostic tests to detect resistant stra…
This study provides compelling evidence for LL-37's potential as a therapeutic agent for psoriasis by directly influencing the inflammatory chemokine milieu. By significantly reducing the secretion and expression of k…
The findings from this review are profoundly significant, as they underscore the potential of host defense peptides (HDPs) as a novel and safer therapeutic class for inflammatory bowel diseases (IBDs). Given the subst…
This research provides a detailed molecular understanding of how hLL-37, a natural antimicrobial peptide, targets and disrupts bacterial membranes through its unique 4-helix bundle structure. This mechanistic insight …
This in silico study provides crucial insights into the potential of antimicrobial peptides as a novel therapeutic strategy against peri-implant infections, especially in the face of growing antibiotic resistance. By …
This research significantly advances our understanding of LL-37's potent antimicrobial mechanisms, providing crucial insights for designing novel peptide-based antibiotics that could circumvent existing resistance pat…
This research highlights a promising strategy to create more durable and infection-resistant dental implants. By leveraging the natural antimicrobial and pro-healing properties of LL-37, these biofunctionalized implan…
This research provides crucial insights into the diverse mechanisms by which antimicrobial peptides exert their effects. Understanding these structural and mechanistic differences is paramount for the rational design …
This systematic review underscores the critical role of genetic factors in modulating inflammatory responses in periodontitis, especially in individuals with underlying genetic or immunological disorders. Understandin…
This study highlights the significant potential of AMP-37 as a novel therapeutic agent to combat the growing threat of multidrug-resistant bacterial infections. Its broad-spectrum activity and efficacy in vivo suggest…
This research highlights cathelicidin's potential as a therapeutic agent for neuroinflammatory conditions by targeting the gut-brain axis. The ability of cathelicidin to simultaneously reduce gut permeability and brai…
This research provides compelling evidence that the prenatal environment is not sterile, but rather harbors a delicate microbial ecosystem that could influence fetal development and future health. Accurate characteriz…
This study highlights that citrullination can profoundly alter the inflammatory potential of LL-37, a crucial antimicrobial peptide. The finding that citrullinated LL-37 reduces COX-2-dependent chemokine responses, de…
This discovery provides crucial insights into the molecular mechanisms underlying the synergistic action of human antimicrobial peptides, which is vital for combating multidrug-resistant bacterial infections. Understa…
This research highlights a novel and effective strategy to enhance the therapeutic potential of ADSCs for various clinical applications. By boosting both their proliferative capacity and intrinsic antibacterial proper…
Understanding the dual nature of LL-37 is critical for developing targeted therapeutic strategies for a range of oral diseases. This comprehensive synthesis of its molecular characteristics and functional roles could …
This research provides compelling evidence that targeting bacterial SufA protease with novel inhibitors represents a viable strategy for developing new antibiotics. The potent in vitro and in vivo antibacterial activi…
This research highlights the potential of a dermofunctional vehicle to therapeutically intervene in skin conditions characterized by inflammation, excessive tissue breakdown, or impaired healing. By downregulating LL-…
A deeper and more integrated understanding of rosacea's pathogenesis is crucial for developing more effective and targeted treatments. This review's findings could pave the way for novel therapeutic strategies that ad…
This research presents a highly promising strategy for treating difficult-to-manage infected skin wounds, particularly those resistant to conventional antibiotics. The injectable, self-healing nature of the hydrogel e…
This study highlights the significant potential of CRISPR/Cas9-engineered phages as a powerful new tool in the fight against antibiotic-resistant bacterial infections. By combining the targeted killing ability of phag…
This multidimensional validation provides robust evidence for the safety and functional benefits of Limosilactobacillus fermentum LF61, positioning it as a highly promising candidate for future probiotic applications.…
This study provides unprecedented atomic-level and kinetic insight into the dynamic mechanism of hLL-37's membrane disruption, a fundamental aspect of its potent antimicrobial function and a key process in innate immu…
This research provides crucial insights into the molecular mechanisms by which GAGs can modulate LL-37 activity, identifying specific structural features that confer potent inhibitory effects. This understanding is a …
This research provides a novel and fundamental understanding of how fever enhances host bacterial defense, suggesting that fever is not just a symptom but an active, beneficial immune strategy. The finding that fever …
This research provides critical insights into how SARS-CoV-2 infection contributes to the heightened risk and severity of cerebral ischemia in COVID-19 patients, highlighting the disturbed regulation of immunothrombos…
This research provides fundamental insights into the complex regulatory mechanisms governing the human cathelicidin peptide LL-37, highlighting how its interaction with host nucleic acids can fine-tune its immune func…
This expanded understanding of HDPs' multifaceted roles could open entirely new therapeutic avenues for a range of cardiovascular and hematological disorders. By elucidating how these peptides influence blood clotting…
This study significantly advances our understanding of how alcohol compromises innate immunity by directly impacting the expression of antimicrobial peptides. The consistent and profound suppression of AMPs, especiall…
This research significantly advances our understanding of how Pseudomonas aeruginosa adapts to establish and maintain chronic infections, providing crucial insights into the mechanisms of bacterial persistence and the…
This comprehensive study provides a strong scientific basis for the traditional use of Cuochuangling Pills in treating rosacea, elucidating its multi-target anti-inflammatory and antioxidant mechanisms. The identifica…