484 studies on Insulin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
Understanding GIP's long-term effects on bone is critically important given the widespread use of GIP receptor (GIPR) agonists like tirzepatide for obesity and type 2 diabetes, conditions often associated with comprom…
This study is crucial as it addresses a significant unmet need for effective anti-obesity treatments in adult congenital heart disease (ACHD) patients, a population often excluded from major clinical trials. If succes…
This study provides compelling evidence that Extra Virgin Olive Oil supplementation can be an effective, non-pharmacological strategy for managing GDM. The significant reduction in the need for insulin therapy suggest…
This reframing of endothelial cells as active regulators of lipid metabolism has significant implications for understanding and treating metabolic disorders. It suggests that targeting specific endothelial functions c…
This comprehensive review underscores the critical role of nutrition in both the development and effective management of insulin resistance. The findings provide a strong evidence base for healthcare professionals and…
This discovery of novel GLP-1 mimotopes represents a significant step forward in the development of new therapeutic agents for type 2 diabetes and obesity. These smaller, potentially more stable, and easier-to-manufac…
This study highlights a crucial aspect of Tirzepatide's efficacy: its ability to preserve fat-free mass during weight loss is strongly linked to enhanced glycaemic control. This finding suggests that Tirzepatide offer…
This research identifies GFRAL as a crucial molecular link between brown fat health and systemic metabolic regulation. Understanding this pathway opens new avenues for therapeutic intervention. Targeting GFRAL could o…
The findings summarized in this review suggest that PentaPeptide-5 and similar multi-receptor agonists represent a significant advancement in the treatment of obesity and type 2 diabetes. By targeting multiple metabol…
The successful demonstration of semaglutide's safety and tolerability in CFRD patients would be a significant step forward, potentially offering a novel therapeutic avenue beyond insulin. If proven safe and effective …
This study holds significant promise for addressing a critical unmet medical need: effective treatment for early-onset, treatment-resistant obesity in young adults. If successful, the RESETTLE Study could establish se…
This study is crucial because it provides real-world evidence supporting Tirzepatide as a highly effective treatment intensification strategy for Type 2 Diabetes patients who are not adequately controlled on GLP-1 RAs…
This case report highlights a rare but serious adverse event associated with tirzepatide use, particularly in individuals without pre-existing diabetes or obesity. Clinicians must be vigilant for symptoms of ketoacido…
These meticulously developed guidelines are profoundly important for enhancing patient safety and optimizing long-term oral health outcomes for the rapidly expanding population of individuals prescribed semaglutide fo…
This study provides compelling evidence for a novel oral-gut-metabolic axis, highlighting how a common salivary bacterium can significantly worsen systemic health. The findings suggest that managing oral infections, p…
This case report is highly significant as it identifies a potential rare but serious adverse event associated with tirzepatide use in a patient population not traditionally considered at high risk for ketoacidosis. It…
This groundbreaking study introduces a highly effective and targeted strategy for delivering thermogenic agents, presenting a novel and potentially safer pathway for obesity treatment. By specifically boosting mitocho…
A deeper understanding of the precise mechanisms underlying beta-cell stress and identity failure is absolutely crucial for the development of novel, disease-modifying therapeutic strategies for type 2 diabetes. This …
This case, if substantiated by detailed clinical data, suggests that Semaglutide could represent a novel and effective therapeutic option for patients with Ulcerative Colitis, particularly those who also suffer from o…
This review significantly advances our understanding of GLP-1's extensive therapeutic potential, moving beyond its established role in metabolic health. The detailed exploration of its neuroprotective mechanisms sugge…
This study powerfully underscores the chronic nature of obesity and the significant challenge of weight regain following tirzepatide discontinuation, emphasizing that sustained pharmacological intervention may be nece…
This research provides crucial insights into the pleiotropic effects of Retatrutide, extending its known benefits beyond weight loss and glycemic control to direct adipose tissue repair. The ability of Retatrutide to …
This real-world data validates the effectiveness of the MiniMed 780G system in maintaining stable glycemic control for children with Type 1 Diabetes (T1D) across varied daily routines. The consistent achievement of in…
This pooled analysis strongly suggests that Tirzepatide is a highly effective add-on therapy for patients with Type 2 Diabetes who are not achieving optimal glycemic control with basal insulin alone. The dual action a…
This research highlights SOCS1-based peptides as a promising new class of therapeutics for complex metabolic and liver diseases. The ability of SOCS1-TP1 to simultaneously ameliorate obesity, insulin resistance, and s…
This pilot study provides compelling evidence that a simple, scalable text messaging program can significantly improve the transition process from basal insulin to GLP-1 RAs, particularly within safety-net populations…
Understanding the unique pathophysiology of Normal-Weight Type 2 Diabetes (NWD) is crucial, as these individuals may not benefit from traditional weight-loss-focused interventions for T2D. This study's findings could …
This trial is critically important because it addresses a significant gap in our understanding of how tirzepatide performs in a vulnerable and growing patient group. The findings could establish a new therapeutic opti…
This study provides novel mechanistic insights into how Semaglutide exerts its therapeutic effects beyond simply delaying gastric emptying. Understanding these specific changes in gastric electrical activity could opt…
This study is pivotal as it explores a novel, multimodal approach to pre-surgical optimization for a high-risk patient population. If successful, the findings could revolutionize the standard of care for obese patient…
This clinical trial is profoundly significant as it explores a novel and promising therapeutic approach for ADPKD, a disease with limited treatment options and a high burden on patients. If successful, this research c…
If tirzepatide proves safe and effective, it could represent a significant therapeutic advancement for individuals with Type 1 Diabetes who struggle with obesity or overweight. Currently, there are limited pharmacolog…
This research provides compelling evidence that alpha-cell dysregulation and subsequent hyperglucagonemia play a central, previously underappreciated role in the development of diabetic cardiomyopathy. By demonstratin…
These findings suggest that MOTS-c could serve as a novel biomarker for PCOS diagnosis or severity, and its genetic variants might identify individuals at higher risk. Understanding this metabolic link opens avenues f…
This case report provides compelling preliminary evidence suggesting a novel therapeutic avenue for Tirzepatide beyond its established metabolic indications. The observed improvements in autonomic dysfunction and POTS…
This case highlights a rare but potentially life-threatening adverse event associated with Tirzepatide use, particularly in individuals without pre-existing diabetes. It underscores the critical importance of educatin…
Understanding the precise role of GHRH (a hormone that stimulates GH release) in acromegaly is crucial for developing more targeted therapies. If endogenous GHRH significantly contributes to GH hypersecretion, then GH…
Understanding the genetic underpinnings of oral semaglutide response is crucial for advancing personalized medicine in prediabetes and obesity. This research could pave the way for personalized treatment strategies, o…
This research holds significant promise for a population in dire need of improved treatment options, as patients with schizophrenia and AUD face unique challenges and poorer prognoses. If successful, this study could …
This trial represents a paradigm shift in Type 1 Diabetes management, potentially transforming daily life for millions by simplifying insulin delivery and reducing mental burden. If successful, tirzepatide could enabl…
This innovative hydrogel represents a significant step towards more effective management of diabetic wounds, offering a smart, on-demand drug delivery system that adapts to the wound's microenvironment. The ability to…
Understanding metformin's brain-mediated actions represents a critical advancement, opening entirely new avenues for optimizing existing T2D treatment strategies and developing innovative therapies. This deeper mechan…
This comprehensive review solidifies the understanding of GLP-1 RAs as promising therapeutic agents for liver diseases, extending their utility beyond metabolic control. By detailing their impact on both metabolic and…
This research highlights the significant therapeutic potential of Psyllium Husk as an accessible and natural adjunct in the comprehensive management of Type 2 Diabetes. The observed improvements in insulin resistance,…