484 studies on Insulin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This review underscores the critical role of pharmacotherapy in modern obesity management, moving beyond traditional lifestyle interventions alone. The significant weight loss and cardiovascular benefits demonstrated …
This comprehensive "Evidence Map" highlights the transformative potential of incretin-based anti-obesity medications as a crucial therapeutic strategy for women suffering from PCOS and obesity. By consolidating existi…
If the study demonstrates positive results, it could establish recombinant human growth hormone (rhGH) as a critical and effective treatment for short stature in children with chronic kidney disease prior to transplan…
The progressive decline of beta-cell function is a hallmark of Type 2 Diabetes Mellitus (T2DM), often leading to increased insulin dependence and uncontrolled blood sugar. If liraglutide were shown to preserve beta-ce…
This study is crucial for advancing personalized medicine in Type 2 Diabetes management. By comparing Semaglutide (a GLP-1 receptor agonist that enhances insulin secretion and reduces appetite) and Dapagliflozin (an S…
This research is significant because it investigates a potential new benefit of tirzepatide beyond weight management and metabolic improvement: reducing breast cancer risk. Given the strong link between obesity and br…
This review significantly advances our understanding of the IGF-IGFBP system as a central player in bone metabolism and osteoporosis. By clarifying its multifaceted roles in regulating bone cell differentiation, it pr…
This study provides important reassurance regarding the cardiovascular safety profile of tirzepatide in a high-risk population. Given tirzepatide's superior efficacy in glycemic control and weight reduction, demonstra…
This study is significant because it could elucidate the precise role of IGF-1 in the pathogenesis of vitiligo, specifically its interaction with oxidative stress. Understanding this mechanism could open new avenues f…
Despite its termination, this study highlights the ongoing effort to understand and optimize treatments for Primary IGF-1 Deficiency, a condition causing significant growth failure in children. The intent was to gathe…
This study highlights the potential for IDegLira to significantly improve the quality of life for very old patients with Type 2 Diabetes by streamlining their treatment. Simplifying medication regimens can enhance adh…
Oral semaglutide could offer a safer, more effective, and convenient alternative to insulin for managing post-transplant hyperglycemia, potentially mitigating risks like hypoglycemia and weight gain in a highly vulner…
This review provides crucial, actionable guidance that can significantly enhance patient safety and reduce perioperative complications for a rapidly expanding patient population. By differentiating the management stra…
While the specific, detailed results from this completed Phase 2 clinical trial (NCT01777542) are not included in the provided record, the study's primary objective was to evaluate the efficacy and safety of recombina…
This Phase 2 trial represents a significant step in exploring targeted treatments for Phelan-McDermid Syndrome, a condition with limited therapeutic options. If IGF-1 proves safe and effective in subsequent studies, i…
While specific quantitative results are not detailed in this summary, the study was designed to rigorously evaluate the efficacy of Liraglutide in a challenging patient population. The primary objective was to determi…
This research is significant because it addresses a critical health disparity, focusing on Mexican American women who are at elevated risk for type 2 diabetes. Improving beta cell function is a direct strategy to halt…
This study provides compelling evidence that insulin administration could be a critical therapeutic strategy for improving survival in non-diabetic patients with sepsis. The observed significant reduction in 28-day mo…
This comprehensive analysis strengthens the evidence for Tirzepatide's potential as a multi-organ protective agent, extending its utility beyond metabolic control. The findings suggest that Tirzepatide could be a valu…
If Liraglutide or Metformin were found to positively influence the telomere-telomerase system or Par-4 in Type 2 Diabetes patients, it would provide novel insights into their mechanisms beyond glucose control. This co…
This study is significant because it provides valuable real-world data on the long-term effectiveness of Xultophy® in a diverse patient population, complementing controlled clinical trial findings. Understanding how a…
This finding suggests that initiating Tirzepatide in patients with type 2 diabetes who are new to GLP-1 receptor agonists may offer a distinct and superior advantage in improving liver health, specifically regarding f…
This review represents a conceptual shift in T2D management, proposing that cognitive preservation should become an explicit therapeutic objective, integrated with metabolic control. The identification of existing glu…
This study highlights tirzepatide's profound potential as an effective add-on therapy for Type 2 Diabetes patients whose blood sugar remains poorly controlled despite existing insulin and metformin regimens. The dual …
This research is significant because it directly addresses a critical unmet need for treatments that can improve connective tissue strength in Ehlers-Danlos Syndrome. If IGF-I proves effective in stimulating collagen …
The concept of continuous subcutaneous hydrocortisone infusion holds significant promise for patients with Addison's Disease, particularly those with co-existing Type 1 Diabetes, by potentially mimicking the body's na…
PCOS is a complex condition with significant unmet needs, particularly for obese and infertile women who struggle with its multifaceted symptoms. If liraglutide demonstrates superior or even comparable efficacy to met…
This foundational Phase 1 study was critical in establishing the initial safety and pharmacokinetic profile of liraglutide, a drug that later became a cornerstone in the treatment of Type 2 Diabetes and obesity. The p…
This study reinforces the efficacy of liraglutide as an add-on therapy for Type 2 Diabetes, particularly within a Japanese population. The findings suggest that combining liraglutide with insulin can lead to better gl…
This study is highly significant because it could establish Tirzepatide as more than just a powerful glucose-lowering agent, potentially offering a crucial benefit in addressing diabetes-related cognitive impairment. …
The findings from this study, once published, will be crucial for understanding the full therapeutic potential of incretin-based therapies beyond current GLP-1 receptor agonists. If the combined GIP and GLP-1 activati…
Given the significant public health burden of Cannabis Use Disorder and the scarcity of effective pharmacological interventions, a successful outcome from this trial could be transformative. Tirzepatide, a dual GLP-1 …
This meta-analysis provides compelling evidence that probiotic supplementation can serve as a safe and effective adjunctive therapy for improving glycemic control in children with Type 1 Diabetes. The observed reducti…
This study provides crucial evidence suggesting that Tirzepatide offers superior weight loss efficacy compared to oral semaglutide, which can significantly inform clinical decision-making for managing overweight and o…
This review highlights the broad therapeutic potential of GLP-1RAs and dual GIP/GLP-1RAs, suggesting they could become cornerstone treatments for a multitude of conditions beyond their current approvals. The identifie…
This systematic review provides a comprehensive synthesis of the endocrine pathways connecting birth size to infant metabolic programming, highlighting the crucial roles of placental hormones and IGF-1. Understanding …
The provided abstract for this observational study does not contain specific quantitative results, such as numerical improvements, percentages of patients experiencing certain outcomes, or statistical significance (p-…