484 studies on Insulin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
The termination of this trial highlights the significant challenges in developing and testing combination therapies for complex conditions like IGF-1 deficiency and short stature. While this specific study did not yie…
Sandostatin LAR is a well-established treatment for acromegaly, and this study aimed to refine our understanding of its comprehensive benefits beyond just hormone suppression. Demonstrating clear improvements in metab…
This study is significant because it explores the practical application of lanreotide Autogel 120 mg at extended dosing intervals, potentially offering a more convenient and less burdensome treatment schedule for pati…
The successful completion of this Phase 3 trial is a significant step towards developing an effective treatment for primary IGF-1 deficiency, a condition with limited therapeutic options. rhIGF-1 (mecasermin) holds su…
This pioneering single-patient study represents an early, crucial exploration into a novel therapeutic approach for a complex and rare genetic disease. Targeting low IGF-1 levels in Werner's Syndrome patients with ost…
This study is crucial because it could establish continuous glucose monitoring (CGM) as a superior standard of care for managing hyperglycemia in hospitalized patients, potentially reducing inflammation and improving …
Understanding Liraglutide's direct effects on inflammation could significantly broaden its therapeutic implications beyond glycemic control and weight management. If Liraglutide can effectively reduce adipose tissue i…
If liraglutide were found to be effective and safe as an add-on therapy for Type 1 Diabetes, it could represent a significant advancement in managing this complex condition. Such a finding could potentially lead to im…
While this specific study did not yield results, the underlying hypothesis of combining GLP-1 agonists with increased Non-exercise Activity Thermogenesis (NEAT) remains highly relevant for optimizing Type 2 Diabetes m…
The concept behind this trial was significant: liraglutide, a GLP-1 receptor agonist, has shown potential in preserving beta-cell function and promoting their survival, which could theoretically enhance the success an…
If successful, this novel approach could offer a significant advancement for patients with Type 2 Diabetes who are dependent on insulin. Reducing or eliminating the need for insulin injections would substantially impr…
The daily burden of carbohydrate counting remains a significant challenge for individuals with Type 1 Diabetes, even with the most advanced closed-loop systems. If weekly Semaglutide proves effective in reducing this …
The successful completion of SURMOUNT-CN is a crucial step towards expanding the availability of effective obesity treatments globally, specifically addressing the needs of the Chinese population. Tirzepatide, a dual …
This research highlights that serum IGF-1 could serve as a valuable biomarker for predicting the progression of anxiety in Parkinson's disease patients, potentially allowing for earlier intervention. Identifying patie…
This study demonstrates that the intramuscular site is a viable and effective location for the transplantation of hPSC-derived pancreatic endocrine cells, offering a less invasive alternative to traditional intraporta…
This review highlights the significant potential of GLP-1 RAs as a superior therapeutic option for steroid-induced diabetes, moving beyond insulin-centric approaches. Their dual benefits of improving glycemic control …
This study identifies a new genetic cause for FPLD2, specifically the c.604G>C (p.Glu202Gln) variant in the LMNA gene, significantly expanding our understanding of its molecular basis. The discovery of novel pathogeni…
The findings from this trial, once fully published, could significantly impact clinical guidelines for managing Type 2 Diabetes in the critical post-hospitalization period. Identifying effective non-insulin options li…
Consistent with the study's primary objective and anticipation, liraglutide demonstrated a significantly greater impact on body weight reduction compared to metformin. Participants receiving liraglutide achieved an av…
Effective management of Type 2 Diabetes often requires combination therapies to achieve optimal glycemic control and address comorbidities like obesity. CagriSema combines semaglutide (a potent GLP-1 receptor agonist)…
The review revealed a consistent and significant dysregulation of both orexin and GLP-1 signaling in post-viral syndromes, suggesting their central role in the manifestation of diverse symptoms. Multiple studies indic…
This study provides crucial real-world evidence that Tirzepatide not only induces substantial weight loss but also favorably alters body composition by preserving lean mass and significantly improving muscle function …
The review affirms that insulin remains a safe, effective, and versatile therapeutic agent for managing diabetes in the inpatient setting, adaptable to a wide range of patient needs and clinical presentations. Evidenc…
This comprehensive review provides a critical, evidence-based framework for clinicians managing Type 2 Diabetes, moving beyond a glucose-centric approach. It underscores the importance of personalized medicine, where …
This review provides crucial insights for refining diabetes management protocols in intensive care settings, highlighting the need for highly individualized approaches. Understanding the specific conditions that dicta…
This review provides crucial, evidence-based guidance that can significantly improve patient safety and surgical outcomes for individuals with diabetes. By offering clear protocols for adjusting diabetes medications i…
This research highlights Kisspeptin's potential as a therapeutic agent for mitigating the adverse effects of maternal hypothyroidism on pregnancy outcomes. The restoration of placental mTOR signaling and glucose homeo…
This mechanistic understanding is crucial because it identifies mitochondrial dysfunction as a central, actionable target for preventing β-cell loss in T2DM. By elucidating the precise links between mitochondrial heal…
This research establishes IGF-1 deficiency as a crucial, previously underappreciated factor in the pathogenesis and prediction of Poor Ovarian Response. The findings suggest that routine screening for IGF-1 levels cou…
This study underscores the significant impact of modifiable lifestyle factors on IGF-1 levels and subsequent breast cancer risk, particularly within vulnerable populations like Palestinian women in the Gaza Strip. The…
This research identifies MLPH as a novel and potent regulator of human hair growth, acting directly on the critical IGF-1 signaling pathway within the dermal papilla. Understanding this mechanism provides a new therap…
This synthesis of evidence underscores the critical role of growth hormone (GH) in driving breast cancer progression, metastasis, and angiogenesis, moving beyond the traditional focus on steroid hormones. Understandin…
This research highlights a critical, previously underappreciated mechanism by which androgenic anabolic steroid (AAS) use may exert its adverse health effects. The disruption of the IGF-PAPP-A-stanniocalcin axis could…
This study represents a significant advancement in standardizing IGF-1 measurement, which is absolutely critical for accurate diagnosis and effective monitoring of endocrine disorders. The enhanced precision, accuracy…
This comprehensive review highlights the critical role of IGF-1 in MASLD pathogenesis, suggesting it's not just a correlative factor but potentially a key player. The most significant implication is that IGF-1 levels …
This study provides compelling evidence that combining BoNT-A with CIMT offers a synergistic approach to not only improve motor function but also actively promote skeletal muscle regeneration in hemiplegic cerebral pa…
This research fundamentally shifts our understanding of IGF-1's role in aging, proposing a biphasic model that moves beyond simple 'more is better' or 'less is better' paradigms. The identification of an IGF-1 senesce…
This research provides compelling evidence that cellular senescence in adipocytes directly contributes to insulin resistance, offering a novel mechanistic link between aging and metabolic disease. The findings suggest…
This study provides compelling evidence that a synthetic ERR agonist can effectively mitigate multiple symptoms of metabolic syndrome in a preclinical model, underscoring the significant therapeutic potential of targe…
This research strengthens the understanding of metformin's mechanism of action beyond its primary glucose-lowering effects, highlighting its sustained impact on GLP-1, a key hormone for glucose homeostasis and appetit…
This research is significant because it demonstrates a novel and highly targeted strategy for treating obesity by directly reducing white adipose tissue (WAT). Unlike many existing weight loss drugs that primarily sup…
The establishment of accurate normative ranges for IGF-1, IGFBP-3, and ALS is profoundly important for pediatric endocrinology. These reference values provide clinicians with the necessary tools to differentiate betwe…
This global registry represents a crucial step in understanding the long-term safety and effectiveness of Increlex® for SPIGFD. By collecting data from a large, diverse patient population over many years, it can ident…
If successful, this research could provide a non-pharmacological strategy to mitigate breast cancer risk in individuals with BRCA mutations. Understanding the impact of diet on biomarkers like IGF-I could empower muta…
This commentary highlights a crucial aspect of drug development: accurately identifying the mechanism of action. If adipotide truly reduces fat by inducing apoptosis of blood vessels in white adipose tissue, it repres…
This study highlights a novel therapeutic strategy for metabolic diseases by targeting the adipose tissue vasculature rather than directly reducing fat mass. The ability to improve glucose tolerance and insulin sensit…