25 studies on Ghrelin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
Bottom line: TitrateLab currently curates 25 dated studies on Ghrelin. The source summaries below describe published research; they do not establish product quality, safety, or clinical suitability.
The discovery of a third ghrelin receptor with distinct properties highlights the greater complexity of the ghrelin system, at least in fish. For researchers and biohackers, this implies that synthetic GHS peptides li…
This study reveals a specific, localized gut-brain-liver axis where intestinal ghrelin acts as a negative regulator of glucose metabolism. For individuals monitoring metabolic health, this suggests that the timing and…
This study identifies UAG(6-13) as a potent, novel therapeutic agent for protecting the heart from ischemia-reperfusion injury. For researchers and clinicians, this finding opens a new avenue for developing treatments…
The study reveals a direct regulatory link where ghrelin stimulates oxytocin, a peptide with known metabolic benefits. This suggests that interventions targeting the ghrelin system could be used to modulate oxytocin l…
This research provides a potential neurological explanation for the severe dyspepsia and appetite loss caused by cisplatin chemotherapy. It suggests that cisplatin treatment dampens the normal signaling response of ke…
This research reveals a novel physiological mechanism where ghrelin acts as a local vasoconstrictor in pancreatic islets during fasting. This action restricts blood flow, thereby limiting the insulin response to hyper…
This research reinforces the ghrelin system's role beyond metabolism, highlighting its inherent neuroprotective and antidepressant functions. For biohackers and researchers, this suggests that modulating the `GHSR` pa…
This research clarifies the direct mechanism by which ghrelin and motilin influence gut rhythm at the cellular level, suggesting they act as key modulators of gastrointestinal motility by directly targeting ICC pacema…
This study identifies ghrelin as a potent neuroprotective agent in a preclinical model of neonatal brain injury, operating through a clearly defined signaling pathway that combats oxidative stress and cell death. For …
This research reveals a specific brain-gut axis mechanism where central ghrelin signaling robustly protects the intestinal barrier against inflammatory damage. For individuals exploring peptides, this highlights a pot…
This research suggests that blocking ghrelin receptors can specifically modulate the hypothalamic response to energy deficit, particularly by preventing the upregulation of `NPY`, a potent appetite stimulant. For rese…
This research provides a strong preclinical rationale for using acylated ghrelin as a potential adjunctive therapy to mitigate the kidney damage caused by doxorubicin chemotherapy. For individuals undergoing DOX treat…
This research highlights a specific mechanism by which ghrelin protects the gut lining, suggesting its potential as a therapeutic agent for inflammatory bowel diseases like ulcerative colitis. For individuals explorin…
This research reinforces the link between ghrelin, mood, and cognitive function, suggesting a specific biological pathway (`cAMP-CREB` -> `BDNF`) through which this occurs. For individuals exploring peptides, this hig…
**Hexarelin and MK-0677 do not bind to the same receptor populations in peripheral tissues** — a distinction with direct implications for anyone selecting between peptidyl and non-peptidyl GHS compounds. For cardiovas…
**The octanoyl fatty-acid modification on ghrelin is non-negotiable for receptor engagement**, directly validating why unacylated ghrelin fragments lack GH-releasing potency. For clinicians and researchers, this confi…
**The identification of `GPR38` as a GHS-R family member with motilin as its ligand** reveals that GH secretagogue pharmacology is entangled with gut-motility signaling — a consideration for clinicians and researchers…
**The cardioprotection afforded by ghrelin and hexarelin appears to be independent of growth hormone secretion**, meaning GH-axis side effects are unlikely to be required for — or necessarily coupled to — the cardiac …
**Des-acyl ghrelin is not metabolically inert** — it directly suppresses fat breakdown at nanomolar concentrations equal to acylated ghrelin, fundamentally revising how practitioners should interpret circulating ghrel…
**The type of GHSR agonist chosen determines not just direct receptor activation but also how the body's own ghrelin pulses are amplified or suppressed.** For clinicians and researchers, this means MK-677's pharmacolo…
**The ago-allosteric model for MK-677 and GHRP-6 is not supported in this assay system** — meaning assumptions about synergistic or supra-additive effects when combining ghrelin-pathway compounds with these secretagog…
This research reframes ghrelin's role in mental health, suggesting its fear-reducing effects are conditional and depend entirely on stress history. For individuals using ghrelin secretagogues like MK-677, this implies…
The findings suggest that the ghrelin system's role in blood pressure and kidney function is significantly different in the context of pre-existing hypertension, which appears linked to a downregulation of `GHS-R1a` r…
**Both ghrelin and its receptor are now fully characterised in a single teleost species**, enabling controlled mechanistic studies of the ghrelin/GHSR axis without cross-species extrapolation. The finding that **ipamo…
This research provides a foundational understanding of which structural parts of GHRPs like Ipamorelin are critical for their function. For peptide users, this knowledge explains why certain analogues are more or less…
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