Secondary 2025 shutdowns
This is one entry from the TitrateLab Vendor Graveyard, a dated, primary-source archive of peptide-market shutdowns, exit scams, and enforcement actions. Documented as mid-to-late 2025. Sources for this entry are named inline below and numbered in full on the parent archive page.
A group of smaller grey-market vendors closed quietly through the 2025 enforcement wave without headline-level attention. Named in community running-lists and industry retrospectives:
- Royal Research — went offline during 2025; no public shutdown announcement.
- Peptide Tech Labs — ceased operations during the same window.
- American Research Labs — shut down during the enforcement surge.
- Unchained Compounds — went offline in 2025 without transition plan.
Each of these failed quietly enough that they generated less forum discussion than the Peptide Sciences / Amino Asylum headlines, but collectively represent a structural narrowing of the vendor pool. When the market audits what remains after the 2025–2026 collapse, the surviving count is smaller than the headline-vendor list suggests because of this secondary tier.
Why it still matters: the enforcement wave disproportionately removed mid-tier operators. The very smallest vendors (too small to draw FDA attention) survived. The very largest faced targeted enforcement. The middle bracket collapsed. Leaves a barbell-shaped 2026 market — a handful of scaled survivors plus a long tail of micro-vendors, with the middle structurally thinner than before.
Primary sources: community-maintained running lists (edparker92 Substack; the Peptide Catalog shutdown tracker); vendor-site DNS-history forensics where the site is no longer resolving. Individual primary-source vendor-announcement pages do not appear to exist for any of the four, which is itself the data point.