Semaglutide trial to assess adjunctive dental cleaning for enhanced metabolic and oral health outcomes in pediatric obesity

Pediatric obesity is a growing global health concern, frequently associated with significant cardiometabolic risks and increased prevalence of periodontal disease. While semaglutide has proven highly effective in managing obesity and improving metabolic markers, its potential synergistic effects with adjunctive oral health interventions remain largely unexplored. This trial addresses a critical gap by examining whether comprehensive care, combining pharmacological obesity treatment with targeted dental interventions, can optimize overall health outcomes for these vulnerable patients.

This is a RANDOMIZED, NONE (no masking specified), TREATMENT clinical trial (NCT07574723) with an estimated n=68 participants. Children with obesity will be randomized to receive either dental cleaning plus oral hygiene instruction or oral hygiene instruction alone. The trial's primary objective is to assess if adjunctive dental cleaning will improve both oral health and metabolic outcomes beyond the effects of semaglutide alone. The study is currently NOT_YET_RECRUITING, with an estimated start date of 2026-05-15 and completion by 2029-12-31.

This is a clinical trial registration (NCT07574723) and, as such, no findings are available yet. The trial is currently NOT_YET_RECRUITING and aims to complete by 2029-12-31. Results will be published after the study concludes, investigating whether adjunctive dental cleaning can enhance the effects of semaglutide in children with obesity by improving oral health and metabolic outcomes.