L-arginine's Impact on Microcirculation, Myogenesis, and Angiogenesis in Older Women with Sarcopenia and Diabetes Investigated

Age-associated sarcopenia and Type 2 Diabetes Mellitus (T2DM) are prevalent conditions in older women, often leading to impaired physical function and reduced quality of life. These conditions are frequently linked to microcirculatory dysfunction, reduced vasoreactivity, and impaired muscle regeneration (myogenesis and angiogenesis). Current interventions often fall short in comprehensively addressing these multifaceted issues. L-arginine, a precursor to nitric oxide, is known for its roles in vasodilation and potentially muscle protein synthesis, making it a candidate for improving vascular and muscle health in these populations.

This study evaluated the effect of L-arginine supplementation in young and old women diagnosed with Sarcopenia or Type 2 Diabetes Mellitus. Participants consumed 5g oral L-arginine daily for 14 days. Microcirculation, vasoreactivity, endothelial function, and vascular smooth muscle function were assessed using Nailfold videocapillaroscopy and venous occlusion plethysmography. Measurements were taken both before and after the 14-day supplementation period to determine the impact of L-arginine.