Randomized trial investigates moderate/vigorous exercise effects on colon cancer risk biomarkers

Strong observational evidence links physical activity inversely with colon cancer risk, independent of diet or body fat, across over 30 studies. However, specifics on the type, timing, and amount of exercise required for a protective effect remain unknown. Understanding the precise mechanisms and biological pathways through which exercise protects the colon is essential to develop targeted prevention strategies. This trial aims to bridge this knowledge gap by investigating how exercise influences colorectal cell proliferation and terminal differentiation.

This is a randomized controlled trial investigating a one-year moderate/vigorous exercise intervention compared to a delayed-exercise control. Participants are individuals who have undergone a colonoscopy within the past 36 months. The study is designed to establish the effects of the exercise intervention on colorectal cell proliferation and terminal differentiation. It will also examine factors within the pathway between exercise and proliferation and apoptosis in both colon and rectal epithelium, aiming to identify how exercise modulates these processes towards a low-risk pattern for colon cancer.