Resistance Exercise Preserves Muscle During GLP-1RA Weight Loss in Overweight Women

GLP-1 receptor agonists (GLP-1RAs) like Tirzepatide are highly effective for weight loss in individuals with obesity and overweight. However, a significant concern is the accompanying loss of lean muscle mass, which can negatively impact metabolic health and functional capacity. This study addresses the crucial knowledge gap of whether a structured resistance exercise program can mitigate this muscle loss and preserve physical function during GLP-1RA treatment.

This randomized study aims to determine if a 20-week progressive resistance exercise program can preserve lean muscle mass and improve physical function in overweight and obese females undergoing GLP-1RA-induced weight loss. Researchers hypothesize that the exercise group will show significantly less lean mass reduction and better functional outcomes compared to controls. The primary objective is to demonstrate that resistance exercise can mitigate muscle loss, leading to a greater preservation of lean mass and improved functional strength. They will measure changes in body composition, muscle strength, and physical performance. The study anticipates that participants in the exercise group will experience a reduced percentage of lean mass loss relative to total weight loss, alongside enhanced functional capacity.