Semax Modulates Brain's Default Mode Network in Healthy Adults

The Default Mode Network (DMN) is a crucial neuronal network in the brain, characterized by its activity during periods of wakeful rest and its involvement in self-referential thought, memory retrieval, and future planning. Dysregulation of the DMN is increasingly recognized as a hallmark in various neurological and psychiatric disorders, including depression, anxiety, and Alzheimer's disease. While nootropic drugs like Semax are known for their cognitive-enhancing properties, the precise mechanisms by which they interact with and alter the functional topography of the DMN, a key player in cognitive and emotional states, remained largely unexplored.